Telomeres shorten during ageing of human fibroblasts
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Summary
The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.
- Type
- article
- Published
- 1990-05-31
- Cited by
- 5,809
- References
- 30
- OpenAlex
- https://openalex.org/W1983673827
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1145492
Keywords
Telomere, Biology, DNA polymerase, Genome instability, DNA replication
References
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- Dynamics of telomere length variation in Tetrahymena thermophila.
- A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
- Human telomeres contain at least three types of G-rich repeat distributed non-randomly.
Cited by
- Shortened telomeres involved in a case with a jumping translocation at 1q21.
- A mammalian factor that binds telomeric TTAGGG repeats in vitro
- Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
- Replicative senescence: the human fibroblast comes of age.
- Recent advances in stem cell neurobiology.
- Telomerase inhibiting activity in vitro from natural resources, marine algae extracts
- Phenotypic changes with immunosuppression in human recipients.
- Telomerase Promoter-Driven Cancer Cell Suicide
- Processing of Alternative DNA Structures in the Human Telomere
- DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs
- Mammalian telomere dynamics: healing, fragmentation shortening and stabilization.
- Induction of tumour cell shedding into effluent venous blood breast cancer surgery.
- Telomeric nucleic acids: C-strand structure and a telomerase RNA mutant
- Replicative Senescence and Cell Immortality: The Role of Telomeres and Telomerase
- Cell aging in vivo and in vitro.
- Replicative Potential and Telomere Length in Human Skeletal Muscle: Implications for Satellite Cell-Mediated Gene Therapy
- Aging and cancer: issues of basic and clinical science.
- Lack of cell cycle regulation of telomerase activity in human cells.
- Preferential accumulation of single-stranded regions in telomeres of human fibroblasts.
- Longevity of lobsters is linked to ubiquitous telomerase expression
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