Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
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Summary
It is reported that at twice the normal number of population doublings, telomerase-expressing human skin fibroblasts and retinal pigment epithelial cells (RPE-hTERT) retain normal growth control in response to serum deprivation, high cell density, G1 or G2 phase blockers and spindle inhibitors.
- Type
- article
- Published
- 1999-01-01
- Cited by
- 706
- References
- 24
- OpenAlex
- https://openalex.org/W1574658543
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10149967
Keywords
Telomerase, Biology, Telomerase reverse transcriptase, Somatic cell, Phenotype
References
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- Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin.
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Cited by
- Telomerase activity in cancer as a diagnostic and therapeutic target.
- TELOMERE-INDEPENDENT REDUCTION OF HUMAN B LYMPHOCYTE: PROLIFERATION DURING LONG-TERM CULTURE
- Immunosenescence phenotypes in the telomerase knockout mouse
- Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression
- Gene amplification of atypical PKC‐binding PARD3 in radiation‐transformed neoplastic retinal pigment epithelial cell lines
- Methylated TRF2 associates with the nuclear matrix and serves as a potential biomarker for cellular senescence
- Telomerase and Human Disease: The Beginnings of the Ends?
- Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells
- Genetic modification of stem cells for cardiac, diabetic, and hemophilia transplantation therapies.
- Characterization of telomeric defects and signal transduction pathways in Dyskeratosis Congenita cells
- Chromosome Missegregation in Alzheimer's Disease Caused by Presenilin 1
- Telomere--the twilight to immortality.
- Chromosome ends in plasmodium falciparum : Dynamics of telomeres, roles of subtelomeres and investigation of telomerase as an antimalarial drug target
- Telomeres and telomerase in aging, regeneration and cancer.
- Laser Bioeffects Resulting from Non-Linear Interactions of Ultrashort Pulses with Biological Systems
- Senescence and its bypass in the vascular endothelium.
- In vitro differentiation capacity of telomerase immortalized human RPE cells.
- Contribution à l'étude du cycle de la cellule endothéliale cornéenne humaine
- Generation of insulin-producing cells from stem cells for cell replacement therapy of type 1 diabetes.
- An Anchorage Nuclear Structure for Telomeric DNA Repeats in HeLa Cells
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