IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
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Summary
A critical role is established for IL-21 in the development of type I diabetes in the NOD mouse, with obvious potential implications for type Iabetes in humans.
- Type
- article
- Published
- 2008-09-16
- Cited by
- 225
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1981365528
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9107972
Keywords
NOD mice, Nod, Biology, Immunology, Endocrinology
References
- Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production
- A Critical Role for IL-21 in Regulating Immunoglobulin Production
- Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.
- IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
- IL‐23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin
- Interleukin-17 stimulates inducible nitric oxide synthase-dependent toxicity in mouse beta cells
- Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
- IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
- IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
- A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
- B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
- Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.
- The NOD mouse: a model of immune dysregulation.
- Functional Waning of Naturally Occurring CD4+ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes
- A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice.
- Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice.
- RegII is a beta-cell protein and autoantigen in diabetes of NOD mice.
- Dynamic interaction between T cell-mediated β-cell damage and β-cell repair in the run up to autoimmune diabetes of the NOD mouse
- T-cell compartments of prediabetic NOD mice.
- Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
Cited by
- Approaches in Immunotherapy, Regenerative Medicine, and Bioengineering for Type 1 Diabetes
- Role of Interleukin 21 in CD4 T cell regulation
- Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.
- Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.
- Étude du mécanisme par lequel la thérapie à l'IL7 induit l'expansion homéostatique des lymphocytes T CD4+
- Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation
- Induction of autoimmune diabetes in non‐obese diabetic mice requires interleukin‐21‐dependent activation of autoreactive CD8+ T cells
- B and T Lymphocyte Attenuator Suppresses IL-21 Production from Follicular Th Cells and Subsequent Humoral Immune Responses
- GVHD新規治療の開発：間葉系幹細胞とIL-21
- A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25− T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice 1
- Lentivirus Gene Engineering Protocols
- Autoimmunity during Thymectomy-Induced Lymphopenia: Role of Thymus Ablation and Initial Effector T Cell Activation Timing in Nonobese Diabetic Mice1
- Transition de l'immunité innée à l'immunité adaptative au cours des maladies chroniques du foie: implication de l'axe "Pattern recognition" récepteurs - Interleukine-6-Th17
- Cell-intrinsic gp130 Signaling on CD4+ T cells Shapes Long-lasting Antiviral Immunity
- Circadian rhythm‐related genes: implication in autoimmunity and type 1 diabetes
- Interleukin-21 Is Associated with the Pathogenesis of Lumbar Disc Herniation.
- Animal models for diabetes: Understanding the pathogenesis and finding new treatments.
- IL-21–Producing Th Cells in Immunity and Autoimmunity
- CD4 T cell differentiation in type 1 diabetes
- Local suppression of IL-21 in submandibular glands retards the development of Sjögren's syndrome in non-obese diabetic mice.
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