Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.
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Summary
The pathogenic mechanisms utilized by the immune system to mediate destruction of the pancreatic beta-cells are outlined, and the islet is highlighted as both driver and target of the disease.
- Type
- review
- Published
- 2012-12-28
- Cited by
- 69
- References
- 158
- Access
- Open access
- OpenAlex
- https://openalex.org/W342420634
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52903469
Keywords
Insulitis, NOD mice, Immunology, Cytotoxic T cell, Proinsulin
References
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- Monoclonal T cells identified in early NOD islet infiltrates.
- Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes
- Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.
- Interferon signalling in pancreatic beta cells.
- Histopathology of type 1 diabetes: old paradigms and new insights.
- The insulin A-chain epitope recognized by human T cells is posttranslationally modified
- B Lymphocyte Depletion by CD20 Monoclonal Antibody Prevents Diabetes in Nonobese Diabetic Mice despite Isotype-Specific Differences in FcγR Effector Functions1
- Suppressor of Cytokine Signaling-1 Overexpression Protects Pancreatic β Cells from CD8+ T Cell-Mediated Autoimmune Destruction1
- Th17 cells in inflammatory conditions.
- The Countervailing Actions of Myeloid and Plasmacytoid Dendritic Cells Control Autoimmune Diabetes in the Nonobese Diabetic Mouse1
- IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.
- Intra‐islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression
- Effector Function of Diabetogenic CD4 Th1 T Cell Clones: A Central Role for TNF-α1
- B cells in autoimmune diabetes.
- The Insulin-Specific T Cells of Nonobese Diabetic Mice Recognize a Weak MHC-Binding Segment in More Than One Form1
- Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations.
- B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice.
- Cutting Edge: Merocytic Dendritic Cells Break T Cell Tolerance to β Cell Antigens in Nonobese Diabetic Mouse Diabetes
- Current approaches to measuring human islet‐antigen specific T cell function in type 1 diabetes
Cited by
- Revealing the specificity of regulatory T cells in murine autoimmune diabetes
- Type 1 diabetes in men : a grounded theory exploration of life with a chronic illness
- Mouse pancreatic beta cells express MHC class II and stimulate CD4+ T cells to proliferate
- Islet inflammation in human type 1 diabetes mellitus
- Therapeutic potential of umbilical cord blood cells for type 1 diabetes mellitus
- Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes
- Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes
- Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes
- Human islet cells are killed by BID-independent mechanisms in response to FAS ligand
- Perforin facilitates beta cell killing and regulates autoreactive CD8+ T‐cell responses to antigen in mouse models of type 1 diabetes
- Isolation and Culture of the Islets of Langerhans from Mouse Pancreas
- Identification of β-cell antigens recognized by human islet-infiltrating T-cells in type 1 diabetes
- Association between telomere length and diabetes mellitus: A meta-analysis
- Emerging role of Hippo signalling in pancreatic biology: YAP re-expression and plausible link to islet cell apoptosis and replication.
- Development of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes
- High‐density lipoprotein immunomodulates the functional activities of macrophage and cytokines produced during ex vivo macrophage‐CD4+ T cell crosstalk at the recent‐onset human type 1 diabetes
- Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
- Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes
- Induction of antigen-specific tolerance and development of autoreactive T cells in an experimental model of autoimmune diabetes
- Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment
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