B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
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Summary
The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases.
- Type
- article
- Published
- 2000-04-01
- Cited by
- 2,328
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2045932062
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7514993
Keywords
CD28, Nod, NOD mice, Autoimmunity, IL-2 receptor
References
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- Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse.
- CD28 costimulation promotes the production of Th2 cytokines.
- Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis.
- B7.2 has opposing roles during the activation versus effector stages of experimental autoimmune thyroiditis.
- CTLA-4 regulates tolerance induction and T cell differentiation in vivo.
- CD28-deficient mice are highly resistant to collagen-induced arthritis.
- Induction of autoimmunity in the absence of CD28 costimulation.
- Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability.
- Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival.
- Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
- B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.
- CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.
- Organ-specific autoimmunity.
- CTLA-4 can function as a negative regulator of T cell activation.
- Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes
- TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype.
- CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus.
- Identification of a monoclonal antibody specific for a murine T3 polypeptide.
Cited by
- Regulatory T cells in experimental colitis.
- Antivirale Immunantwort und Virus-induzierte Apoptose von Insulin-produzierenden Zellen in der Pathogenese des Typ 1 Diabetes
- Induction of tolerance by adoptive transfer of Treg cells.
- Increased Entry into the IFN-γ Effector Pathway by CD4+ T Cells Selected by I-Ag7 on a Nonobese Diabetic Versus C57BL/6 Genetic Background1
- Development of Spontaneous Autoimmune Peripheral Polyneuropathy in B7-2–Deficient Nod Mice
- Natural regulatory CD4 T cells expressing CD25.
- The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells.
- Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).
- Selective Action of the Photosensitizer QLT0074 on Activated Human T Lymphocytes ¶
- In vivo imaging of autoimmune disease in model systems.
- CD4+CD25+ and CD4+CD25− T Cells Act Respectively as Inducer and Effector T Suppressor Cells in Superantigen-Induced Tolerance1
- Treatment of type 1 diabetes with anti-T-cell agents: From T-cell depletion to T-cell regulation
- A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
- The Role of Non‐Deletional Tolerance Mechanisms in a Murine Model of Mixed Chimerism with Costimulation Blockade
- Prevention of toxic epidermal necrolysis by regulatory T cells
- Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression
- Mechanisms of CTLA-4-Ig in tolerance induction.
- Short administration of polyclonal anti-T cell antibody (ALS) in NOD mice with extensive insulitis prevents subsequent development of autoimmune diabetes.
- Dendritic cells expand antigen‐specific Foxp3+CD25+CD4+ regulatory T cells including suppressors of alloreactivity
- Drug Insight: new immunomodulatory therapies in type 1 diabetes
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- I-E+ nonobese diabetic mice develop insulitis and diabetes
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- Both central and peripheral tolerance mechanisms play roles in diabetes prevention in NOD-E transgenic mice
- Effect of X‐ and Y‐Box Deletions on the Development of Diabetes in H‐2Eα‐Chain Transgenic Nonobese Diabetic Mice
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- Pig islet xenografts are resistant to autoimmune destruction by non‐obese diabetic recipients after anti‐CD4 treatment