A Critical Role for IL-21 in Regulating Immunoglobulin Production
Explore this paper's citation graph
Summary
It is demonstrated that, although mice deficient in the receptor for IL-21 (IL-21R) have normal lymphoid development, after immunization, these animals have higher production of the immunoglobulin IgE, but lower IgG1, than wild-type animals, suggesting that these γc-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID.
- Type
- article
- Published
- 2002-11-22
- Cited by
- 1,062
- References
- 28
- OpenAlex
- https://openalex.org/W1985577573
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6210513
Keywords
Biology, Immunology, Cytokine, Immunoglobulin E, Common gamma chain
References
- Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants.
- Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells.
- Defective IL7R expression in T-B+NK + severe combined immunodeficiency
- Development and Maintenance of a B220− Memory B Cell Compartment1
- Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response.
- IL-4 is protective against development of toxoplasmic encephalitis.
- Long-term chimerism and B-cell function after bone marrow transplantation in patients with severe combined immunodeficiency with B cells: A single-center study of 22 patients.
- Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex1
- Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.
- Nonrandom X chromosome inactivation in B cells from carriers of X chromosome-linked severe combined immunodeficiency.
- IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
- IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation.
- Cytokines and immunodeficiency diseases
- Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain.
- Intrinsic defects of B cell function in X‐linked severe combined immunodeficiency
- Cell-mediated immunity to Toxoplasma gondii: initiation, regulation and effector function.
- Characterization of B cells in severe combined immunodeficiency disease.
- Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
- Antigen-Specific B Cell Memory
- B-cell function in canine X-linked severe combined immunodeficiency.
Cited by
- A new modality for immunosuppression: targeting the JAK/STAT pathway
- Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells
- Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus
- The capacity of Th2 lymphocytes to deliver B‐cell help requires expression of the transcription factor STAT3
- Regulation of IL-17A Production Is Distinct from IL-17F in a Primary Human Cell Co-culture Model of T Cell-Mediated B Cell Activation
- STAT3 and the Hyper-IgE syndrome
- Cytokines in Common Variable Immunodeficiency as Signs of Immune Dysregulation and Potential Therapeutic Targets – A Review of the Current Knowledge
- Plasticity and complexity of B cell responses against persisting pathogens.
- Follicular Helper T (Tfh) Cells Mediate IgE Antibody Response to Airborne Allergens
- Citrobacter rodentium: A Model Enteropathogen for Understanding the Interplay of Innate and Adaptive Components of Type 3 Immunity
- Conditioning murine B cells for immunoglobulin A production In vitro
- Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?
- Role of Interleukin 21 in CD4 T cell regulation
- The immunobiology of IL-27.
- Novel cytokines in the treatment of malignancies.
- The role of cytokines in the mechanism of adverse drug reactions.
- Signals for B cell activation in antibody response
- Molecular pathogenesis of multiple myeloma: chromosomal aberrations, changes in gene expression, cytokine networks, and the bone marrow microenvironment.
- Lymphocytes T CD4 et immunité anti-tumorale naturelle : impact de la chimiothérapie, émergence de lymphocytes T CD4 cytotoxiques
- Biology of IgE production: IgE cell differentiation and the memory of IgE responses.
Related papers
- Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities*
- The levels of TNF alpha, IL4 and IL10 production by T-cells in B-cell chronic lymphocytic leukaemia (B-CLL).
- The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling.
- A8.4 IL4–10 synerkine: a novel anti-inflammatory drug to inhibit immunopathology in inflammatory rheumatic diseases
- FRI0009 Il4-10 synerkine: a novel anti-inflammatory drug to inhibit immunopathology in rheumatic diseases
- The role of soluble common gamma chain in autoimmune disease
- Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: experiments of nature continue to point the way.
- The common .GAMMA. chain of multiple cytokine receptors: Its implication in T cell development.
- The Interleukin-17 Receptor B Subunit Is Essential for the Th2 Response to Helicobacter pylori, but Not for Control of Bacterial Burden