AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen.
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Summary
It is suggested that, in vivo, cell fusion involving the CD4 molecule may represent a mechanism whereby uninfected cells can be incorporated into AIDS virus infected syncytia.
- Type
- article
- Published
- 1986-05-30
- Cited by
- 503
- References
- 25
- OpenAlex
- https://openalex.org/W1972872628
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24975274
Keywords
Syncytium, Giant cell, Cell fusion, Multinucleate, Antigen
References
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- Direct fluorescent labeling of cells with fluorescein or rhodamine isothiocyanate. I. Technical aspects.
- Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
- Selective neutralization of ecotropic murine leukemia virus by monoclonal antibodies: localization of a site on the gp70 protein associated with ecotropism.
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- Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.
- The role of T4 in immune function and dysfunction.
- Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4
- Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1
- Human Immunodeficiency Virus Infection of Human Bone Derived Cells
- Apoptotic killing of CD4+ T lymphocytes in HIV-1-infected PHA-stimulated PBL cultures is mediated by CD8+ LAK cells.
- Sterilization of HIV with irradiation: relevance to infected bone allografts.
- Development of a Cell-Based Enzyme-Linked Immunosorbent Assay for High-Throughput Screening of HIV Type 1 Entry Inhibitors Targeting the Coreceptor CXCR4
- HIV-1 Entry in SupT1-R5, CEM-ss, and Primary CD4+ T Cells Occurs at the Plasma Membrane and Does Not Require Endocytosis
- Mechanism of HIV-1 entry into CD4+ T cells.
- The endocytic pathway for human immunodeficiency virus infection.
- Mediators of fusion between HIV-infected macrophages and lymphoid cells.
- Fusion of human immunodeficiency virus-infected cells with uninfected cells.
- Diseño, síntesis y estructura de dominios helicoidales. Influencia de la introducción de aminoácidos D.
- How does HIV-1 infect a susceptible human cell?: Current thinking.
- Liposomes generated from proliposomes for treatment of glioma using Momordica charantia extracts
- Pathology of the Nervous System
- Characterisation of the HIV-1 subtype C Env gene and the expression of the Env protein from selected isolates in mammalian cells
- Apoptosis during HIV infection. A cytopathic effect of HIV or an important host-defense mechanism against viruses in general?
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