A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains
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Summary
A cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells found to be expressed in human and murine T lymphoblasts, thymocytes and phytohaemagglutinin-stimulated T lymphocytes suggests that the cDNA clone may correspond to a message that specifies part of the human T-cell receptor.
- Type
- article
- Published
- 1984-03-01
- Cited by
- 1,210
- References
- 35
- OpenAlex
- https://openalex.org/W2017963255
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4229210
Keywords
Complementary DNA, Immunoglobulin light chain, Molecular biology, Biology, Homology (biology)
References
- Expression and function of idiotypes of lymphocytes.
- Hypervariable regions, idiotypy, and the antibody-combining site.
- Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.
- Exon/intron organization and complete nucleotide sequence of an HLA gene.
- Modulation of T leukaemic cell phenotype with phorbol ester
- The differentiation and function of human T lymphocytes.
- Nucleotide sequences of the murine retrovirus Friend SFFVp long terminal repeats: identification of a structure with extensive dyad symmetry 5' to the TATA box.
- Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.
- Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends.
- The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype
- Induction of differentiation in human T-lymphoblastic leukemia cell lines by 12-O-tetradecanoylphorbol 13-acetate (TPA): studies with monoclonal antibodies to T cells.
- Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein.
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
- Human Antibody Genes: V Gene Variability and CH Gene Switching Strategies
- 5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency.
- Clustered arrangement of immunoglobulin λ constant region genes in man
- The mouse T cell receptor: structural heterogeneity of molecules of normal T cells defined by xenoantiserum.
- Thy-1 cDNA sequence suggests a novel regulatory mechanism
- Antibody structure and molecular immunology.
- T-cell antigen receptors: fact and artefact.
Cited by
- In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes.
- The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones.
- Flow cytometric analysis of human lymphocytes using affinity-purified antibody to T cell receptor beta synthetic J region peptide.
- Gastric small lymphocytic proliferation with immunoglobulin gene rearrangement in pseudolymphoma versus lymphoma.
- Contrasuppression in the mucosal immune system
- Molecular cloning of the zeta chain of the T cell antigen receptor.
- Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin
- Antigen-specific, I-A-restricted suppressor hybridomas with spontaneous cytolytic activity. Functional properties and lack of rearrangement of the T cell receptor beta chain genes
- The change of specificity, karyotype, and antigen-receptor gene expression is correlated in cytotoxic T-cell lines.
- A third type of murine T-cell receptor gene
- Regulation of memory CD8 T cell differentiation
- The T-cell Receptor as Immunoglobulin: Paradigm Regained
- Clonal composition of T cells in lymphomatoid papulosis.
- Intrathymic differentiation: Introductory remarks on problems and approaches
- Athymic mice express a high level of functional γ-chain but greatly reduced levels of α- and β-chain T-cell receptor messages
- Short communication: generation of recombinant monoclonal antibodies against an immunodominant HLA-A*2402-restricted HIV type 1 CTL epitope.
- Immunological and genotypic analysis of human Tγ-lymphoproliferative disorders
- Characterization of natural autoantibodies: A case for functional significance
- Recent progresses in the phenotypic and functional characterization of human cytolytic T lymphocytes
- D-J joining and D-J proteins in B cells and T cells.
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