Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1

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Summary

It is concluded that primary isolates of HIV-1 infect inefficiently following contact with surfaces of CD4-positive cells, and it is proposed that this confers a selective disadvantage during passage in rapidly dividing leukemia cell lines.

Type
article
Published
1994-04-01
Cited by
164
References
53

Keywords

Doctrine, Philosophy, Incarnation, Theology, Hymn

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