Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1
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Summary
It is concluded that primary isolates of HIV-1 infect inefficiently following contact with surfaces of CD4-positive cells, and it is proposed that this confers a selective disadvantage during passage in rapidly dividing leukemia cell lines.
- Type
- article
- Published
- 1994-04-01
- Cited by
- 164
- References
- 53
- OpenAlex
- https://openalex.org/W8139036
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22408268
Keywords
Doctrine, Philosophy, Incarnation, Theology, Hymn
References
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- Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity
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- Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism
- The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
- AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen.
Cited by
- Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1
- Roles of CD4 and Coreceptors in Binding, Endocytosis, and Proteolysis of gp120 Envelope Glycoproteins Derived from Human Immunodeficiency Virus Type 1*
- Cell surface receptors for gammaretroviruses.
- Analysis of CCR5 diversity in the South African population
- A subset of human CD34+ hematopoietic progenitors express low levels of CD4, the high-affinity receptor for human immunodeficiency virus-type 1.
- The humoral immune response to HIV-1: Consequences for vaccine design.
- Cell Entry of Enveloped Viruses
- Glucocorticoids Regulate TCR-Induced Elevation of CD4: Functional Implications1
- Macrophage-tropic and T-cell line-adapted chimeric strains of human immunodeficiency virus type 1 differ in their susceptibilities to neutralization by soluble CD4 at different temperatures
- An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif Protein
- Continued Utilization of CCR5 Coreceptor by a Newly Derived T-Cell Line-Adapted Isolate of Human Immunodeficiency Virus Type 1
- Phenotypic Correlates of HIV-1 Macrophage Tropism
- Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
- Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates
- Resistance to human immunodeficiency virus type 1 (HIV-1) generated by lentivirus vector-mediated delivery of the CCR5Δ32 gene despite detectable expression of the HIV-1 co-receptors
- The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study
- CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable.
- Amplified and tissue-directed expression of retroviral vectors using ping-pong techniques
- Segregation of CD4 and CXCR4 into Distinct Lipid Microdomains in T Lymphocytes Suggests a Mechanism for Membrane Destabilization by Human Immunodeficiency Virus
- Properties of HTLV-I transformed CD8+ T-cells in response to HIV-1 infection.
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