Shortened Telomeres in Serous Tubal Intraepithelial Carcinoma: An Early Event in Ovarian High-grade Serous Carcinogenesis
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Summary
The finding of short telomeres in a vast majority ofSTICs provides further support to the proposal that STICs are precursors of HGSC and opens new areas of research in elucidating the early events of ovarian high-grade serous carcinogenesis.
- Type
- article
- Published
- 2010-06-01
- Cited by
- 147
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972706951
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25442530
Keywords
Telomere, Serous fluid, Serous carcinoma, Carcinogenesis, Biology
References
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- A candidate precursor to serous carcinoma that originates in the distal fallopian tube (J Pathol 2007; 211: 26–35)
- Differential roles of telomere attrition in type I and II endometrial carcinogenesis.
- Analysis of DNA Copy Number Alterations in Ovarian Serous Tumors Identifies New Molecular Genetic Changes in Low-grade and High-grade Carcinomas
- Telomerase activity in ovarian tumors
- Human cell senescence as a DNA damage response.
- BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair*
- Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase
- Molecular genetics for the clinician
- Telomere Shortening Occurs Early During Breast Tumorigenesis: A Cause of Chromosome Destabilization Underlying Malignant Transformation?
- Elevated level of 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls
- Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
- Advances in the Recognition of Tubal Intraepithelial Carcinoma: Applications to Cancer Screening and the Pathogenesis of Ovarian Cancer
Cited by
- Vorläuferläsionen der Ovarialkarzinome
- SOX2 Expression and Prognostic Significance in Ovarian Carcinoma
- Advances in serous tubal intraepithelial carcinoma: correlation with high grade serous carcinoma and ovarian carcinogenesis.
- Oncomorphic Tp53 mutations in advanced serous ovarian carcinomas
- Ovarialkarzinom und Präkanzerosen
- Chirurgie annexielle prophylactique des femmes à risque héréditaire : vers de nouvelles pistes ?
- Society of Gynecologic Oncology recommendations for the prevention of ovarian cancer
- Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)
- Elucidation of Molecular Alterations in Precursor Lesions of Ovarian Serous Carcinoma
- Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling
- Precursors of ovarian cancer in the fallopian tube: Serous tubal intraepithelial carcinoma – an update
- [Early epithelial lesions in prophylactic annexectomies in patients at high risk of ovarian cancer: Report of a series of 93 cases].
- Ovarian Cancer Is an Imported Disease: Fact or Fiction?
- Molecular Pathogenesis and Extraovarian Origin of Epithelial Ovarian Cancer. Shifting the Paradigm
- Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma
- Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma
- Microenvironment and Pathogenesis of Epithelial Ovarian Cancer
- Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas
- Fallopian tube precursors of ovarian low‐ and high‐grade serous neoplasms
- Radical fimbriectomy: a reasonable temporary risk-reducing surgery for selected women with a germ line mutation of BRCA 1 or 2 genes? Rationale and preliminary development.
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- Telomere length dynamics in telomerase-positive immortal human cell populations.
- Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
- Telomerase inhibition alters telomere maintenance mechanisms in laryngeal squamous carcinoma cells
- Clonal Heterogeneity in Telomerase Activity and Telomere Length in Tumor‐Derived Cell Lines
- Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation.