Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma
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Summary
It is confirmed that amplification of CCNE1 is a frequent molecular genetic change in uterine serous carcinoma, and the identification ofCCNE1 amplification in many endometrial intraepithelial carcinomas suggests that this genetic event occurs early during tumor progression.
- Type
- article
- Published
- 2014-07-01
- Cited by
- 63
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979642982
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7299159
Keywords
Serous carcinoma, Serous fluid, Comparative genomic hybridization, Carcinoma, Pathology
References
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- TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma—evidence supporting the clonal relationship of the two lesions
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- Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay
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Cited by
- Targeting Cyclin-Dependent Kinases and Cell Cycle Progression in Human Cancers.
- The Mutational Landscape of Endometrial Cancer
- Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes.
- The history and future of targeting cyclin-dependent kinases in cancer therapy
- Molecular Characterization of Undifferentiated Carcinoma Associated With Endometrioid Carcinoma
- Novel Molecular Markers for Breast Cancer
- Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs.
- Immunohistochemical Profiling of Endometrial Serous Carcinoma
- Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo
- CCNE1 Amplification and Centrosome Number Abnormality in Serous Tubal Intraepithelial Carcinoma- Further Evidence Supporting its Role as a Precursor of Ovarian High-Grade Serous Carcinoma
- Cyclin E as a potential therapeutic target in high grade serous ovarian cancer.
- Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Uterine Tumors.
- Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer
- CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis
- Pathology of Endometrial Carcinoma.
- Bioinformatic identification of prognostic signature defined by copy number alteration and expression of CCNE1 in non-muscle invasive bladder cancer
- Cell cycle regulation and anticancer drug discovery
- Precision Molecular Pathology of Uterine Cancer
- Recent advances in CDK inhibitors for cancer therapy.
- HetRCNA: A Novel Method to Identify Recurrent Copy Number Alternations from Heterogeneous Tumor Samples Based on Matrix Decomposition Framework
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