Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Explore this paper's citation graph
Summary
It is demonstrated that tankyrase 1 inhibition in human cancer cells enhances telomere shortening by a telomerase inhibitor and hastens cell death, implying that both enzyme activity and accessibility to telomeres can be targets for telomersase inhibition.
- Type
- article
- Published
- 2005-01-01
- Cited by
- 161
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W2005903392
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7758922
Keywords
Telomere, Telomerase, Downregulation and upregulation, Telomerase reverse transcriptase, Telomere-binding protein
References
- Inhibition of telomerase limits the growth of human cancer cells
- Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining.
- Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
- Telomere maintenance by recombination in human cells
- Telomerase maintains telomere structure in normal human cells.
- Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.
- Telomere Shortening Is Proportional to the Size of the G-rich Telomeric 3′-Overhang*
- A DNA damage checkpoint response in telomere-initiated senescence
- Progressive cis‐inhibition of telomerase upon telomere elongation
- Specific association of human telomerase activity with immortal cells and cancer.
- Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
- The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.
- The Telomeric Poly(ADP-ribose) Polymerase, Tankyrase 1, Contains Multiple Binding Sites for Telomeric Repeat Binding Factor 1 (TRF1) and a Novel Acceptor, 182-kDa Tankyrase-binding Protein (TAB182)*
- Connecting chromosomes, crisis, and cancer.
- Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.
- POT1 as a terminal transducer of TRF1 telomere length control
- TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres.
- A survey of telomerase activity in human cancer.
- Mammalian telomeres end in a large duplex loop.
- Poly(ADP-ribose) polymerase
Cited by
- RADIOSENSITIZATION OF CANCER STEM CELLS: TARGETING TGFβ, NOTCH OR TELOMERASE TO IMPROVE TUMOR RESPONSE O RADIOTHERAPY
- Targeting Telomerase
- Expression alteration of tankyrase and telomerase in HCC development in rats
- Selective inhibition of human tankyrases
- The identification and validation of Auger electron-emitting radiopharmaceuticals targeting telomerase for cancer therapy
- Inhibitors of the tankyrases, triple-function targets in the cancer cell
- Epithelial stromal interaction in breast cancer
- MST-312 Alters Telomere Dynamics, Gene Expression Profiles and Growth in Human Breast Cancer Cells
- Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma
- The characterisation of telomere dynamics in Myelodysplastic syndromes
- Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells
- Therapeutic targeting of replicative immortality
- Telomeres and telomerase as targets for anticancer drug development.
- Telomeres and telomerase: Biological and clinical importance in dogs.
- NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
- Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer
- Telomerase regulation and stem cell behaviour.
- TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)
- G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3′ telomeric overhang in cancer cells
- Telomerase Enzyme Inhibition (TEI) and Cytolytic Therapy in the Management of Androgen Independent Osseous Metastatic Prostate Cancer
Related papers
- Telomerase caught in the act
- Telomeres and Telomerase: Implications for Cancer and Aging
- Telomeres and telomerase in aging and cancer.
- The telomere and telomerase: how Do they interact?
- Progress on Telomerase and Cellular Immortalization
- The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
- How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis
- Clonal Heterogeneity in Telomerase Activity and Telomere Length in Tumor‐Derived Cell Lines
- Clonal Heterogeneity in Telomerase Activity and Telomere Length in Tumor-Derived Cell Lines (44505)
- Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation.