BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair*
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Summary
It is shown that human cancer cells containing mutated BRCA1 are hypersensitive to ionizing radiation and this hypersensitivity can be reversed by the expression of forms of BRC a1 that are not growth suppressing.
- Type
- article
- Published
- 1999-06-25
- Cited by
- 251
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2022176772
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25492427
Keywords
Radioresistance, DNA repair, Transactivation, Biology, DNA damage
References
- A human BRCA1 gene knockout
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- Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl
- Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.
- A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins
- Association of BRCA1 with Rad51 in mitotic and meiotic cells.
- BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
- Transcriptional activation by BRCA1
- DNA repair ability of cultured cells derived from mouse embryos in comparison with human cells.
- Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression
- Involvement of Brca2 in DNA repair.
- Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing.
- BRCA1 required for transcription-coupled repair of oxidative DNA damage.
- Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
- Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation
- Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells.
- Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
- Identification of the breast cancer susceptibility gene BRCA2
- Finkel-Biskis-Reilly Mouse Osteosarcoma Virus v-fosInhibits the Cellular Response to Ionizing Radiation in a Myristoylation-dependent Manner*
- BRCA1 mutations in primary breast and ovarian carcinomas.
Cited by
- Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability
- Role of BRCA1 and BRCA2 in DNA Repair and Potential Impact on Therapeutics
- Genetic variation and radiation quality impact cancer promoting cellular phenotypes in response to HZE exposure.
- Reproductive factors in relation to breast cancer characterized by p53 protein expression (United States)
- Characterisation of BRCA1 genomic rearrangements in South African breast and/or ovarian cancer families
- The expression and regulation of matrilysin (MMP-7) in human colon cancer and leukaemia cell lines
- The Contribution of Inherited Factors to the Clinicopathological Features and Behavior of Breast Cancer
- Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.
- Transcription — guarding the genome by sensing DNA damage
- Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937
- Antibody-Mediated BRCC36 Silencing: A Novel Approach for Targeted Breast Cancer Therapy
- Methylation of breast cancer susceptibility gene 1 (BRCA1) predicts recurrence in patients with curatively resected stage I non–small cell lung cancer
- Analysis of Rad9 Functions; Roles in the Checkpoint Response, DNA Damage Processing, and Prevention of Genomic Instability
- Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res., 60: 390-394, 2000.
- Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes.
- Cancer risk comparative perception and overscreening behaviours of non-carriers from BRCA1/2 families.
- Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer?
- Breast Cancer Screening in Women with a Familial or Genetic Predisposition: the role of MRI
- BRCA1 Mutation: A Predictive Marker for Radiation Therapy?
- Identification and Characterization of Novel Kinases that Regulate BRCA1 Expression and Function
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