Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
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Summary
It is shown here that this important subset of developmental regulator genes, termed bivalent genes, assemble RNAP complexes phosphorylated on Ser 5 and are transcribed at low levels, providing an insight into the molecular mechanisms that allow ES cells to self-renew and yet retain the ability to generate multiple lineage outcomes.
- Type
- article
- Published
- 2007-12-01
- Cited by
- 719
- References
- 40
- OpenAlex
- https://openalex.org/W1967269362
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2317691
Keywords
RNA polymerase II, Biology, Repressor, Histone, Gene
References
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- An extensive network of coupling among gene expression machines
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- CIITA regulates transcription onset via Ser5‐phosphorylation of RNA Pol II
- Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
- Breaking barriers to transcription elongation
- A Heterogeneous Expression Pattern for Nanog in Embryonic Stem Cells
- Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.
- Chromatin signatures of pluripotent cell lines
- Production of Monoclonal Antibodies Against Mammalian Ring1B Proteins
- Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain.
- Role of histone H2A ubiquitination in Polycomb silencing
Cited by
- The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes
- The many faces of ubiquitinated histone H2A: insights from the DUBs
- Sweet Silencing
- Mechanisms of Polycomb gene silencing: knowns and unknowns
- Developmental gene regulation in the era of genomics.
- Polycomb-group mediated epigenetic mechanisms through plant evolution.
- An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy.
- Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms
- A double take on bivalent promoters.
- The Molecular Nature of Very Small Embryonic-Like Stem Cells in Adult Tissues
- The Epigenetic Paradox of Pluripotent ES Cells.
- Etude du réseau transcriptionnel du gène Xist, acteur principal de l'inactivation du chromosome X
- Maintenance of Hox gene expression patterns.
- Dynamic histone modifications at the promoters of Hox genes in embryonic stem cells
- EZH2: a pivotal regulator in controlling cell differentiation.
- Significance of Protein Interactions in Mediating AF9 Function
- The molecular mechanism of the aberrant expression of the B-cell specific PAX5 gene in t(8;21) AML
- Changing Fate: Cellular Reprogramming
- The role of PcG and TrxG proteins in executing epigenetic memory
- Molecular subclassification of medulloblastoma and its utility for disease prognostication
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