Mitochondrial dynamics in cell death and neurodegeneration
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Summary
This review highlights the current understanding of abnormal mitochondrial dynamics relevant to neuronal synaptic loss and cell death in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington’s disease.
- Type
- review
- Published
- 2010-06-25
- Cited by
- 303
- References
- 163
- Access
- Open access
- OpenAlex
- https://openalex.org/W1970565325
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28683079
Keywords
Neurodegeneration, Programmed cell death, Dynamics (music), Mitochondrion, Neuroscience
References
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- OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28
- Clinical and electrophysiologic features of CMT2A with mutations in the mitofusin 2 gene
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- Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.
- Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization*[boxs]
- Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria*
- Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
- MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission
- The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
Cited by
- Gene Expression in the Addicted Brain
- Mitochondrial Fusion Proteins and Human Diseases
- Overexpression of Rcan1-1L Inhibits Hypoxia-Induced Cell Apoptosis through Induction of Mitophagy
- Peroxiredoxin 5 prevents amyloid-beta oligomer-induced neuronal cell death by inhibiting ERK-Drp1-mediated mitochondrial fragmentation.
- Ultrastructural Evidence for Impaired Mitochondrial Fission in the Aged Rhesus Monkey Dorsolateral Prefrontal Cortex
- Regulación de la dinámica mitocondrial en neuronas sometidas a excitotoxicidad
- Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance
- Taking shape : regulating mitochondria morphology through alternative splicing and phosphorylation of fission factor proteins
- Characterization of SLP-2 function in T lymphocytes
- Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1α pathway
- Rôle de la dysfonction mitochondriale dans deux maladies neurodégénératives, la Maladie de Huntington et la Maladie de Parkinson
- Mitochondrial Dysfunction and Reactive Oxygen Species in Neurodegeneration
- PINK1/Parkin-mediated mitophagy alleviates chlorpyrifos-induced apoptosis in SH-SY5Y cells.
- Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition.
- The impact of mild traumatic brain injury on neuronal networks and neurobehavior
- Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells.
- Retinal Neuronal Remodelling in a Model of Optic Atrophy
- Cellular function and toxicity of the Parkinson’s disease-related genes α-synuclein and catp-6 in C. elegans
- Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells
- Mitochondrial morphology and dynamics in Triticum aestivum roots in response to rotenone and antimycin A
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