Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization*[boxs]
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Summary
This work has created an activated mutant of Mfn2, which shows increased rates of nucleotide exchange and decreased rates of hydrolysis relative to wild type Mfn1, and provides the first evidence that Mfn 2 is a signaling GTPase regulating mitochondrial fusion and that the nucleotide-dependent activation of M fn2 concomitantly protects the organelle from permeability transition.
- Type
- article
- Published
- 2005-07-01
- Cited by
- 336
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972044649
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23644745
Keywords
MFN2, MFN1, Intermembrane space, mitochondrial fusion, Cell biology
References
- Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast.
- Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
- hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery*
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- Dynamics of mitochondrial morphology in healthy cells and during apoptosis
- Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
- Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis*
- Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
- A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast
- OPA1 requires mitofusin 1 to promote mitochondrial fusion.
- Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion.
- The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway.
- Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism.
- Electrical coupling and plasticity of the mitochondrial network.
- Kinetics of Interaction of Rab5 and Rab7 with Nucleotides and Magnesium Ions*
- Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion.
- Mitochondrial GTPase mitofusin 2 mutation in Charcot–Marie–Tooth neuropathy type 2A
- GTPase activity of Rab5 acts as a timer for endocytic membrane fusion
- Mitochondrial membrane remodelling regulated by a conserved rhomboid protease
Cited by
- Role of hFis1 in mitochondrial fission and apoptosis
- Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology
- Superoxide production is inversely related to complex I activity in inherited complex I deficiency.
- Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
- A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators
- Role of pp2a/bβ2 and pka/akap1 in brain development and function via dynamin-related protein 1 (drp1) control of mitochondria shape and bioenergetics
- Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study
- Regulación de la dinámica mitocondrial en neuronas sometidas a excitotoxicidad
- Homeostatic functions of BCL-2 proteins beyond apoptosis.
- Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
- Taking shape : regulating mitochondria morphology through alternative splicing and phosphorylation of fission factor proteins
- Mitochondria on guard: role of mitochondrial fusion and fission in the regulation of apoptosis.
- A NOVEL CARDIAC FUNCTION OF SUMO2/3 AND SENP5 DEPENDENT PATHWAY AND ITS PHYSIOLOGICAL IMPACT ON CONGESTIVE CARDIOMYOPATHY
- Structure and function of a mitochondrial PP2A holoenzyme that regulates neuronal survival
- Mitochondrial Dynamics: The Intersection of Form and Function
- Oxygen-sensing and Mitochondrial Control of Cell Function
- Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease
- IMSBP, une protéine identifiée comme une cible de la S100B, impliquée dans la distribution subcellulaire des mitochondries.
- Cell signaling by Rho and Miro GTPases : studies of Rho GTPases in cytoskeletal reorganizations and of Miro GTPases in mitochondrial dynamics.
- Disease mechanisms in mitochondrial maintenance disorders
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