TGFβ signalling in context
Explore this paper's citation graph
Summary
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed and the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings.
- Type
- review
- Published
- 2012-09-20
- Cited by
- 2,911
- References
- 164
- OpenAlex
- https://openalex.org/W1970098795
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205495323
Keywords
Context (archaeology), Transforming growth factor, Signalling, Signalling pathways, Relevance (law)
References
- Alterations in components of the TGF-beta superfamily signaling pathways in human cancer.
- Mechanism of activation of the TGF-β receptor
- Smad4 and FAST-1 in the assembly of activin-responsive factor
- Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
- How cells read TGF-beta signals.
- Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.
- Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.
- Epithelial-mesenchymal transitions in development and disease.
- Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia.
- Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas
- Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors
- Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions.
- Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom
- The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
- Systems control of BMP morphogen flow in vertebrate embryos
- A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.
- Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities.
- A poised chromatin platform for TGF-β access to master regulators
- Specificity of latent TGF-ß binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin
- OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
Cited by
- Signaling by the TGFβ superfamily.
- The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding
- Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
- Cancer cells remodel themselves and vasculature to overcome the endothelial barrier
- Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
- Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos*
- Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse
- ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation
- Computational Detection of Stage-Specific Transcription Factor Clusters during Heart Development
- An in vivo gain-of-function screen identifies the Williams-Beuren Syndrome gene GTF2IRD1 as a mammary tumor promoter
- TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster
- SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors
- TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands
- Novel TGF-β inhibitors ready for prime time in onco-immunology
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- Tuning of major signaling networks (TGF-β, Wnt, Notch and Hedgehog) by miRNAs in human stem cells commitment to different lineages: Possible clinical application.
- Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology
- TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1
- The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis.
- VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma
Related papers
- Ethylene signalling and response pathway: a unique signalling cascade with a multitude of inputs and outputs
- Abiotic stress signalling pathways: specificity and cross-talk.
- Sugar sensing and signalling networks in plants.
- Early events in signalling by interferons.
- Cell Signalling
- Fellowship of the rings: a saga of strigolactones and other small signals.
- The interplay between light and jasmonate signalling during defence and development.
- Signalling in light-controlled development.
- Signal transduction of transforming growth factor-β family and tumor