VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma

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Summary

In-vitro studies revealed that pVHL interacted with ALK5 to downregulate its expression through K48-linked poly-ubiquitination and proteasomal degradation, thus negatively controlling TGF-β induced cancer cell invasiveness.

Type
article
Published
2018-03-08
Cited by
19
References
40
Access
Open access

Keywords

Anorexia, Medicine, Internal medicine

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