VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma
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Summary
In-vitro studies revealed that pVHL interacted with ALK5 to downregulate its expression through K48-linked poly-ubiquitination and proteasomal degradation, thus negatively controlling TGF-β induced cancer cell invasiveness.
- Type
- article
- Published
- 2018-03-08
- Cited by
- 19
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W29662646
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4711999
Keywords
Anorexia, Medicine, Internal medicine
References
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- Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
- Analysis of VHL gene alterations and their relationship to clinical parameters in sporadic conventional renal cell carcinoma
- pVHL: A Multipurpose Adaptor Protein
- TGFβ signalling in context
- Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer.
- Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters
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- VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma
- The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
- Prognostic relevance of tumour size in T3a renal cell carcinoma: a multicentre experience.
- Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus*
- Non-Smad signaling pathways
- TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer
- Evaluation of the prognostic significance of perirenal fat invasion and tumor size in patients with pT1-pT3a localized renal cell carcinoma in a comprehensive multicenter study of the CORONA project. Can we improve prognostic discrimination for patients with stage pT3a tumors?
- Telomere length in peripheral blood predicts survival in clear cell renal cell carcinoma.
Cited by
- miR-22 Regulates Invasion, Gene Expression and Predicts Overall Survival in Patients with Clear Cell Renal Cell Carcinoma
- miRNA-21 promotes cell proliferation and invasion via VHL/PI3K/AKT in papillary thyroid carcinoma
- Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma
- Hypoxia-induced epithelial to mesenchymal transition in cancer
- Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases
- The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation
- pVHL-mediated SMAD3 degradation suppresses TGF-β signaling
- The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis
- The precision medicine approach to cancer therapy: part 1 — solid tumours
- The Tumor Microenvironment of Clear-Cell Ovarian Cancer
- The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells
- A Boolean network model of hypoxia, mechanosensing and TGF-β signaling captures the role of phenotypic plasticity and mutations in tumor metastasis
- Liquid biomarkers associate with TGF-β Type I receptor and hypoxia in kidney cancer
- Von Hippel–Lindau/Hypoxia Inducible Factor Axis in Glioblastoma
- pVHL status in clear cell renal cell carcinoma regulates HIF-α and E-cadherin expression levels and their implications for tumor progression
- Prognostic gene screening and experimental validation in renal clear cell carcinoma based on spatial transcriptomics and single-cell sequencing
- The role of transforming growth factor ‐ β signaling and hypoxia ‐ inducible factors in renal cell carcinoma
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