SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors
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Summary
The data suggest that SMAD dependent signaling is involved in the detrimental effects of SMARCB1-deficiency and provide a rationale for the investigation of TGFbeta targeted treatments in ATRT.
- Type
- article
- Published
- 2017-01-20
- Cited by
- 8
- References
- 31
- OpenAlex
- https://openalex.org/W28108836
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19250415
Keywords
Humanities, Philosophy
References
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- Comparative gene expression analysis of Dtg, a novel target gene of Dpp signaling pathway in the early Drosophila melanogaster embryo.
- High‐resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors
- TGF-β as a therapeutic target in high grade gliomas - promises and challenges.
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- Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.
Cited by
- Downregulation of SMARCB1/INI1 expression in pediatric chordomas correlates with upregulation of miR-671-5p and miR-193a-5p expressions
- Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors
- Recent Developments in Using Drosophila as a Model for Human Genetic Disease
- Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors
- Advancing biology based therapeutic approaches for atypical teratoid rhabdoid tumors.
- Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors
- Embryonal Tumors: Atypical Teratoid/Rhabdoid Tumor (ATRT)
- CMAR_A_289544 479..498
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