Systems control of BMP morphogen flow in vertebrate embryos
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Summary
Dorsal-ventral (D-V) patterning of the frog gastrula by Bone Morphogenetic Proteins (BMPs) is one of the best studied examples of a self-regulating embryonic patterning system.
- Type
- review
- Published
- 2011-09-19
- Cited by
- 47
- References
- 74
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973689839
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:148282
Keywords
Morphogen, Biology, Gastrulation, Bone morphogenetic protein, Embryonic stem cell
References
- Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
- Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs.
- Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins.
- Control of Dpp morphogen signalling by a secreted feedback regulator
- Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos
- Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development.
- A gradient of BMP activity specifies dorsal-ventral fates in early Xenopus embryos.
- Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation.
- The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
- Specificity of Drosophila Cytonemes for Distinct Signaling Pathways
- A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineages.
- HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.
- Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.
- Organism-scale modeling of early Drosophila patterning via Bone Morphogenetic Proteins
- Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms
- von Willebrand Factor Type C Domain-containing Proteins Regulate Bone Morphogenetic Protein Signaling through Different Recognition Mechanisms*
- Scaling of the BMP activation gradient in Xenopus embryos
- A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling
- Signalling by TGF-beta family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin.
- Spemann's organizer and self-regulation in amphibian embryos
Cited by
- The Extracellular Regulation of Bone Morphogenetic Proteins in Drosophila and Sawfly Wing
- Investigation of regulatory functions of microRNAs in skin and hair follicle development and cycling : a role of microRNA-214 in skin and hair follicle homeostasis
- BMP growth factor signaling in a biomechanical context
- Follistatin-like 1 in vertebrate development.
- Boning up on glypicans—opportunities for new insights into bone biology
- TGFβ signalling in context
- BMP/Smad signaling and embryonic cerebellum development: Stem cell specification and heterogeneity of anterior rhombic lip
- Self-organized shuttling: generating sharp dorsoventral polarity in the early Drosophila embryo.
- Potential Roles of Bone Morphogenetic Protein (BMP)-9 in Human Liver Diseases
- A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear
- RGM regulates BMP-mediated secondary axis formation in the sea anemone Nematostella vectensis.
- Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints
- Expression and Functional Study of Extracellular BMP Antagonists during the Morphogenesis of the Digits and Their Associated Connective Tissues
- Regulation of TGFβ and related signals by precursor processing.
- Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
- Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development
- BMP9 Is a Proliferative and Survival Factor for Human Hepatocellular Carcinoma Cells
- BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development.
- Spatial regulation of BMP activity
- Fine‐tuning BMP7 signalling in adipogenesis by UBE2O/E2‐230K‐mediated monoubiquitination of SMAD6
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- Computational analysis of BMP gradients in dorsal-ventral patterning of the zebrafish embryo.
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