A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.

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Summary

It is proposed that single-stranded DNA generated in response to oncogene-induced replication stress compromises the repair of deaminated cytosines and other damaged bases, leading to the observed SNS mutator phenotype.

Type
article
Published
2012-12-01
Cited by
66
References
57
Access
Open access

Keywords

Exome sequencing, Phenotype, Biology, Genetics, Genome instability

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