Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.
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Summary
PCDH10 is a gastric tumor suppressor; its methylation at early stages of gastric carcinogenesis is an independent prognostic factor.
- Type
- article
- Published
- 2009-02-01
- Cited by
- 210
- References
- 33
- OpenAlex
- https://openalex.org/W2010736881
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5173665
Keywords
Cancer research, Protocadherin, Methylation, Bisulfite sequencing, Epigenetics
References
- The fundamental role of epigenetic events in cancer
- A gene hypermethylation profile of human cancer.
- Concurrent hypermethylation of multiple tumor‐related genes in gastric carcinoma and adjacent normal tissues
- Induction of G2/M arrest and apoptosis by water extract of Strychni Semen in human gastric carcinoma AGS cells
- Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia.
- Profile of Aberrant CpG Island Methylation Along the Multistep Pathway of Gastric Carcinogenesis
- Promoter hypermethylation of tumor‐related genes in gastric intestinal metaplasia of patients with and without gastric cancer
- Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression
- Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation.
- Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
- Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer.
- Methylation pattern of CDH13 gene in digestive tract cancers
- Inactivation of helicase‐like transcription factor by promoter hypermethylation in human gastric cancer
- Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies
- Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer
- Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer
- Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma.
- CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer.
- AZD2171 Shows Potent Antitumor Activity Against Gastric Cancer Over-Expressing Fibroblast Growth Factor Receptor 2/Keratinocyte Growth Factor Receptor
- Frequent Aberrant Methylation of the CDH4 Gene Promoter in Human Colorectal and Gastric Cancer
Cited by
- Aberrant Gene Methylation in the Lymph Nodes Provides a Possible Marker for Diagnosing Micrometastasis in Gastric Cancer
- Expression of protocadherin8: Function as a tumor suppressor in hypopharyngeal carcinoma
- The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21
- Dapper Homolog 1 Is a Novel Tumor Suppressor in Gastric Cancer through Inhibiting the Nuclear Factor-κB Signaling Pathway
- Promoter methylation of tumor-related genes in gastric carcinogenesis.
- Methylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach.
- Annexin A6 is down-regulated through promoter methylation in gastric cancer.
- Wnt2 promotes non-small cell lung cancer progression by activating WNT/β-catenin pathway.
- Hypermethylation in gastric cancer.
- Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer
- Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer
- Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway
- XRCC1 downregulated through promoter hypermethylation is involved in human gastric carcinogenesis
- Klotho is silenced through promoter hypermethylation in gastric cancer.
- Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers
- Epigenetic silencing of Aristaless‐like homeobox‐4, a potential tumor suppressor gene associated with lung cancer
- Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer
- Homeobox D10 Gene, a Candidate Tumor Suppressor, Is Downregulated through Promoter Hypermethylation and Associated with Gastric Carcinogenesis
- Protocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma
- Novel biomarkers for the identification and targeted therapy of gastric cancer
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