The causes and consequences of genetic heterogeneity in cancer evolution
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Summary
Insight is gained into the common pathways of tumour evolution that could support the development of future therapeutic strategies and shape the evolution of the cancer genome through a plethora of mechanisms.
- Type
- review
- Published
- 2013-09-18
- Cited by
- 2,140
- References
- 135
- OpenAlex
- https://openalex.org/W2041993682
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4457392
Keywords
Genome instability, Biology, Genetic heterogeneity, Cancer, Phenotype
References
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- Mutation selection and the natural history of cancer
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- The hallmarks of cancer
- The landscape of cancer genes and mutational processes in breast cancer
- Intra-tumour heterogeneity: a looking glass for cancer?
- Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal
- Rate, molecular spectrum, and consequences of human mutation
- Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.
- Genetic instability and darwinian selection in tumours.
- Dual pathway spindle assembly increases both the speed and the fidelity of mitosis
- Histological and molecular types of breast cancer: is there a unifying taxonomy?
- High chromosomal instability in brain metastases of colorectal carcinoma.
- Association between BRCA2 but not BRCA1 Mutations and Beneficial Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients with Ovarian Cancer
- Mechanisms and impacts of chromosomal translocations in cancers
Cited by
- Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer
- Mutations of epigenetic regulatory genes are common in thymic carcinomas
- Genome-wide detection of intervals of genetic heterogeneity associated with complex traits
- A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases
- Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
- Amplification of TLK2 Induces Genomic Instability via Impairing the G2/M Checkpoint
- The Role of Genomic Profiling in Advanced Breast Cancer: The Two Faces of Janus
- Intratumoral heterogeneity of CD44v6 in rectal cancer
- RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- Modeling Tumor Clonal Evolution for Drug Combinations Design
- DNA Damage and Repair Biomarkers of Immunotherapy Response
- “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway
- Genome Medicine for Brain Tumors: Current Status and Future Perspectives
- Predicting clinical outcomes using cancer progression associated signatures
- Development of Novel Tools for Radial Glia Lineage Tracing and Modeling Central Nervous System Tumor
- High sensitivity analysis of BRAF mutations in neoplastic and non-neoplastic thyroid lesions
- In situ Sequencing : Methods for spatially-resolved transcriptome analysis
- A computational approach for comparative oncogenomics using mouse models
- Nanoflares as probes for cancer diagnostics.
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