The mitochondrial permeability transition pore and its role in cell death.

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Summary

Current evidence that the pore complex is involved in outer-membrane rupture and release of these proteins during programmed cell death is reviewed, along with indications that transient pore opening may provoke 'accidental' apoptosis.

Type
article
Published
1999-07-15
Cited by
2,517
References
21
Access
Open access

Keywords

Mitochondrial permeability transition pore, Voltage-dependent anion channel, Cell biology, Intermembrane space, Programmed cell death

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