The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

Keywords

Apoptosome, Intermembrane space, Cytochrome c, Translocase of the inner membrane, Mitochondrial apoptosis-induced channel

References

• Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosisCamilla Köhler, Annie Gahm, Takafumi Noma — 1999
• A conserved cysteine in molybdenum oxotransferases.Michael Barber, Peter J. Neame — 1990
• Mitochondrial regulation in sea urchins. II. Formation of polyribosomes within the mitochondria of 4-8 cell stage embryos of the sea urchin.Michael A. Innis, Sydney P. Craig — 1978
• A function for lipoxygenase in programmed organelle degradationKlaus van Leyen, Robert M. Duvoisin, Harald Engelhardt — 1998
• The oxidation of exogenous cytochrome c by mitochondriaMårten Wikström, Robert P. Casey — 1985
• Injected cytochrome c induces apoptosisBoris Zhivotovsky, Sten Orrenius, Odd Terje Brustugun — 1998
• Double identity for proteins of the Bcl-2 familyJohn C. Reed — 1997
• The hydrogen hypothesis for the first eukaryoteWilliam Martin, Miklós Müller — 1998
• Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial PhasesH. Michael Ellerby, Séamus J. Martin, Lisa Ellerby — 1997
• Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDACShigeomi Shimizu, Masashi Narita, Yoshihide Tsujimoto — 1999
• Bcl-2 prolongs cell survival after Bax-induced release of cytochrome cThierry Rossé, Reynald Olivier, Laurent Monney — 1998
• X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell deathSteven W. Muchmore, Michael Sattler, Heng Liang — 1996
• Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c.Mohanish Deshmukh, Eugene M. Johnson — 1998
• Cytochrome c activation of CPP32‐like proteolysis plays a critical role in a Xenopus cell‐free apoptosis systemRuth M. Kluck, Seamus J. Martin, Brian M. Hoffman — 1997
• Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.Matthew G. Vander Heiden, Navdeep S. Chandel, Edward K. Williamson — 1997
• Simultaneous release of adenylate kinase and cytochrome c in cell deathBarbara Single, Marcel Leist, Pierluigi Nicotera — 1998
• Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria BlockedJie Yang, Xuesong Liu, Kapil N. Bhalla — 1997
• Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.Masashi Narita, Shigeomi Shimizu, Toshinori Ito — 1998
• Cell-specific Induction of Apoptosis by Microinjection of Cytochrome cFeng Li, Anu Srinivasan, Yu Wang — 1997
• Mitochondrial Proliferation and Paradoxical Membrane Depolarization during Terminal Differentiation and Apoptosis in a Human Colon Carcinoma Cell LineMariangela Mancini, Benjamin O. Anderson, Elizabeth Caldwell — 1997

Cited by

• The ‘harmless’ release of cytochrome cWei Zhou — 2000
• c-Myc Sensitization to Oxygen Deprivation-induced Cell Death Is Dependent on Bax/Bak, but Is Independent of p53 and Hypoxia-inducible Factor-1*Жанна Валерьяновна Петрунина, Александр Альфредович Шунейко — 2004
• The Bcl-2 family: roles in cell survival and oncogenesisEnric Marco Granell — 2003
• Mitochondria as functional targets of proteins coded by human tumor viruses.Julia Preece, Ruud van der Veen, Wapula N. Raditloaneng — 2005
• The heat shock protein 90 inhibitor 17‐AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9S. Wigman — 2006
• The mitochondrial death pathway.L. L. Lao, J. R. Ferron, T. S. Taylor — 2008
• Investigations into the molecular mechanism of apoptosisKerry J. Gilmore — 2000
• Ceramide Channels and the Induction of Apoptosis: Structural Insights on Channel Formation and Regulation by Bcl-2 Family ProteinsMeenu N. Perera — 2012
• Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosisM.-A. Belaud-Rotureau, Nathalie Leducq, F. Macouillard Poulletier de Gannes — 2000
• Induction of Apoptosis in Rat Myocardium under Anoxic ConditionsV. B. Saprunova, S. A. Kazimirchuk, Anton A. Tonshin — 2002
• OPA1-dependent cristae remodeling disassembles respiratory chain supercomplexes, triggering apoptotic mitochondrial dysfunctionSara Cogliati — 2011
• Régulation du Pore de Transition de Perméabilité mitochondrial et toxicité induite par les analogues de l'ubiquinone dans les hépatocytes cancéreux.F. Devun — 2008
• GALIG : UN NOUVEAU GÈNE HUMAIN INDUCTEUR DE LA MORT CELLULAIREMélanie Duneau — 2005
• Protein permeability pathways in the mitochondrial outer membrane during apoptosisGanesan Vidyaramanan — 2012
• Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent PathwayDaniel P. Bailey — 2005
• Apoptosis, redox stress and cancer.T. Moodley — 2013
• Dissipation of Potassium and Proton Gradients Inhibits Mitochondrial Hyperpolarization and Cytochrome c Release during Neural ApoptosisMonika Poppe, C. Reimertz, Heiko Düßmann — 2001
• INVESTIGATING THE MOLECULAR MECHANISMS OF BCL-2 AND BAX IN THE REGULATION OF APOPTOSISM. Annis — 2004
• Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generationMaria Victoria Niklison-Chirou, Augusto Bellomio, Fernando G. Dupuy — 2008
• Cytochrome c release from mitochondria: all or nothingJean‐Claude Martinou, Solange Desagher, Bruno Antonsson — 2000

Related papers

• A tale of two mitochondrial channels, MAC and PTP, in apoptosisKathleen W. Kinnally, Bruno Antonsson — 2007
• Bcl-2 and the Outer Mitochondrial Membrane in the Inactivation of Cytochrome c during Fas-mediated Apoptosis*Souichi Adachi, Andrew R. Cross, Bernard Babior — 1997
• Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transitionJared L. Scarlett, Michael P. Murphy — 1997
• Greasing the path to BAX/BAK activation.Émilie Hollville, Séamus J. Martin — 2012
• Mitochondrial targeting of tBid/Bax: a role for the TOM complex?Martin Ott, Erik Norberg, Boris Zhivotovsky — 2009
• Bcl-2-family proteins and the role of mitochondria in apoptosis.Tomomi Kuwana, Donald D. Newmeyer — 2003
• Mitochondrial intermembrane junctional complexes and their role in cell deathMartin Crompton — 2000
• Potential mechanisms of mitochondrial cytochrome‐C release during apoptosisAnne N. Murphy — 1999
• How proapoptotic proteins can escape from mitochondria?Vladimir P. Skulachev — 2000