The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion
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Summary
ZnT8 is involved in normal glucagon release and acts via Ca2+-independent mechanisms and is important in a subset of α-cells for normal responses to hypoglycemia, according to a study investigating the role of Slc30a8 in the control of glucagon secretion.
- Type
- article
- Published
- 2015-07-15
- Cited by
- 55
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1959797863
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7026973
Keywords
Internal medicine, Endocrinology, Glucagon, Islet, Biology
References
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- Islet β-cell secretion determines glucagon release from neighbouring α-cells
- An immunocytochemical and morphometric study of the rat pancreatic islets.
- DICER Inactivation Identifies Pancreatic β-Cell “Disallowed” Genes Targeted by MicroRNAs
- Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
- Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
- Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
- A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion
- Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.
- SLC30A8 mutations in type 2 diabetes
- The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance.
- Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
- Glucose Regulates Free Cytosolic Zn2+ Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells
- Rapid three-dimensional imaging of individual insulin release events by Nipkow disc confocal microscopy.
- A genome-wide association study identifies novel risk loci for type 2 diabetes
- Protein Tyrosine Phosphatases as Targets of the Combined Insulinomimetic Effects of Zinc and Oxidants
- Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)
- Insulin Signaling in α-cells Modulates Glucagon Secretion in vivo
- Beta cell specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallization and secretion
- The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel.
Cited by
- Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology
- The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion
- Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?
- Is zinc an intra-islet regulator of glucagon secretion?
- Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats.
- Zinc and diabetes.
- Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia
- Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production
- Lack of Association between SLC30A8 Variants and Type 2 Diabetes in Mexican American Families
- Role of the type II diabetes-associated gene SLC30A8 in the pancreatic α-cell
- High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting
- Effects of insulin therapy on glucagon in patients with newly diagnosed type 2 diabetes
- Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice
- The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice
- Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes
- GcgCreERT2 knockin mice as a tool for genetic manipulation in pancreatic alpha cells
- Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism
- SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients
- Relations intercellulaires dans les îlots de Langerhans et leur rôle dans la sécrétion du glucagon
- The α-cell in diabetes mellitus
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