The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion
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- Type
- article
- Published
- 2016-01-01
- Cited by
- 29
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2209743361
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206559032
Keywords
Secretion, Dynamics (music), Chemistry, Insulin, Biophysics
References
- The beta-cell in human type 2 diabetes.
- An immunocytochemical and morphometric study of the rat pancreatic islets.
- NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells.
- The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion
- K(ATP) channels and insulin secretion: a key role in health and disease.
- TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+
- Macrophages and islet inflammation in type 2 diabetes
- Expression of Ca2+‐permeable two‐pore channels rescues NAADP signalling in TPC‐deficient cells
- Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets
- ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+(*)
- Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
- Glucose Stimulates Ca2+ Influx and Insulin Secretion in 2-Week-old β-Cells Lacking ATP-sensitive K+ Channels*
- NAADP mobilizes calcium from acidic organelles through two-pore channels
- Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.
- THE BETA CELL LESION IN TYPE 2 DIABETES: THERE HAS TO BE A PRIMARY FUNCTIONAL ABNORMALITY
- Pancreatic β‐cell mass in European subjects with type 2 diabetes
- Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
- Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2.
- Lipotoxicity disrupts incretin-regulated human β cell connectivity.
- Visualising insulin secretion. The Minkowski Lecture 2004
Cited by
- Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice
- Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions
- A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion
- Local and regional control of calcium dynamics in the pancreatic islet
- The regulation of autophagy by calcium signals: Do we have a consensus?
- Electrical Excitability of the Endoplasmic Reticulum Membrane Drives Electrical Bursting and the Pulsatile Secretion of Insulin in a Pancreatic Beta Cell Model
- Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2+ mobilization from acidic stores in pancreatic α-cells
- Control of insulin secretion by GLP‐1
- Two-pore channels and disease
- Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain.
- Automated microfluidic droplet sampling with integrated, mix-and-read immunoassays to resolve endocrine tissue secretion dynamics
- Friend and foe: β-cell Ca2+ signaling and the development of diabetes
- Effects on Pancreatic Beta and other Islet Cells of the Glucose-dependent Insulinotropic Polypeptide.
- Metabolic regulation of calcium signaling in beta cells.
- Targeting Two-Pore Channels: Current Progress and Future Challenges
- Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals
- Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect
- Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination
- The Role of cAMP in Beta Cell Stimulus–Secretion and Intercellular Coupling
- TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?
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