Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
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Summary
It is concluded that SREBP1c over-expression, even when confined to a subset of beta-cells, leads to defective insulin secretion from islets and may contribute to some forms of Type II diabetes.
- Type
- article
- Published
- 2004-03-15
- Cited by
- 119
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1992480737
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13318933
Keywords
Glucokinase, Biology, Lipogenesis, Internal medicine, Fatty acid synthase
References
- Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas.
- AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?
- AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.
- A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.
- Sterol Regulation of Fatty Acid Synthase Promoter
- Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.
- Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
- Fixation of Ejaculated Spermatozoa for Electron Microscopy
- Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression.
- 5′-AMP-activated Protein Kinase Controls Insulin-containing Secretory Vesicle Dynamics*
- Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism.
- Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.
- Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?
- The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.
- Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells.
- REPRODUCIBLE HIGH YIELD OF RAT ISLETS BY STATIONARY IN VITRO DIGESTION FOLLOWING PANCREATIC DUCTAL OR PORTAL VENOUS COLLAGENASE INJECTION1
- Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells.
- Identification of functional ionotropic glutamate receptor proteins in pancreatic β‐cells and in islets of Langerhans
- The Transcription Factor SREBP-1c Is Instrumental in the Development of β-Cell Dysfunction*
- Synchronization of glucose-induced Ca2+ transients in pancreatic beta-cells by a diffusible factor.
Cited by
- Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell function
- Bimodal role of conventional protein kinase C in insulin secretion from rat pancreatic β cells
- EASD News Section October 2004
- Roles of vitamin A status and retinoids in glucose and fatty acid metabolism.
- Regulación de la expresión génica por glucosa
- The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion
- Chronic palmitate exposure inhibits AMPKα and decreases glucose-stimulated insulin secretion from β-cells: modulation by fenofibrate
- Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.
- The mitochondrial uncoupling-protein homologues
- The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance.
- Grape seed procyanidins improve β-cell functionality under lipotoxic conditions due to their lipid-lowering effect.
- Role of AMPK in pancreatic beta cell function.
- Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion
- Sterol regulatory element‐binding protein‐1c knockdown protected INS‐1E cells from lipotoxicity
- Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk
- Translationally controlled tumour protein (TCTP) is a novel glucose-regulated protein that is important for survival of pancreatic beta cells
- Imaging glucose-regulated insulin secretion and gene expression in single islet β-cells
- Role of hypothalamic 5′-AMP-activated protein kinase in the regulation of food intake and energy homeostasis
- AICAR Reversed the Glucolipotoxicity Induced β-cell Dysfunction through Suppression of PPAR-γ-coactivator-1 (PGC-1) Overexpression
- SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective
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