A genome-wide association study identifies novel risk loci for type 2 diabetes
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Summary
Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
- Type
- article
- Published
- 2007-02-22
- Cited by
- 3,105
- References
- 56
- OpenAlex
- https://openalex.org/W2025143098
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4302932
Keywords
TCF7L2, Genetics, Biology, Genotyping, Genome-wide association study
References
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- Demonstrating stratification in a European American population
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- Case‐Control Association Tests Correcting for Population Stratification
- Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
- Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
- Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction
- The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes
- From genotypes to genes: doubling the sample size.
- High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.
Cited by
- Zinc as a Potential Coadjuvant in Therapy for Type 2 Diabetes
- Principal component analysis in high dimensional data: application for genomewide association studies
- Genetics of flystrike, dagginess and associated traits in New Zealand dual-purpose sheep : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand
- Models and methods for genome -wide association studies
- The families of zinc (SLC30 and SLC39) and copper (SLC31) transporters.
- Hierarchical Bayes prioritization of marker associations from a genome‐wide association scan for further investigation
- The role for endoplasmic reticulum stress in diabetes mellitus.
- A survey of allelic imbalance in F1 mice.
- Die Herzinsuffizienz als komplexe genetische Erkrankung
- Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15–34 years) but not in middle-aged (40–59 years) diabetic patients
- Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening
- MODY-like diabetes associated with an apparently balanced translocation: possible involvement of MPP7 gene and cell polarity in the pathogenesis of diabetes
- Therapeutic approaches based on beta-cell mass preservation and/or regeneration.
- [Genome-wide association study between bone mineral density and SNPs in Japanese postmenopausal women].
- Mining the Human Phenome using Semantic Web Technologies: A Case Study for Type 2 Diabetes
- Gene–Nutrient Interactions in the Metabolic Syndrome
- Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
- Genetic variants of the protein kinase C-beta 1 gene and development of end-stage renal disease in patients with type 2 diabetes.
- Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups
- Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
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