The role for endoplasmic reticulum stress in diabetes mellitus.
Explore this paper's citation graph
Summary
This review addresses the transition from physiology to pathology, namely how and why the physiological UPR evolves to a proapoptotic ER stress response and which defenses are triggered by beta-cells against these challenges.
- Type
- article
- Published
- 2008-01-15
- Cited by
- 1,183
- References
- 293
- Access
- Open access
- OpenAlex
- https://openalex.org/W18048764
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13812809
Keywords
Population, Quality (philosophy), Environmental science, Risk analysis (engineering), Business
References
- Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
- Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians.
- Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-α in patients with recent-onset type 1 diabetes
- Signal integration in the endoplasmic reticulum unfolded protein response
- Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.
- Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.
- Protein folding in the endoplasmic reticulum and the unfolded protein response.
- Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose.
- A 22 bp cis‐acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.
- Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-κB and pp38 mitogen-activated protein kinase
- Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): Mechanism of action
- EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
- Demography. Broken limits to life expectancy.
- Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
- Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
- Joslin's Diabetes Mellitus
- Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway
- Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes*
- Islet beta cell failure in type 2 diabetes.
- Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress*
Cited by
- Estrès del reticle endoplasmàtic, inflamació i resistència a la insulina en cèl•lules musculars esquelètiques
- Glucose regulation of β‐cell stress in type 2 diabetes
- Rôle du stress du réticulum endoplasmique et de l’autophagie dans la régulation des réponses immune et angiogénique activées par des stress ischémiques et inflammatoires dans l’épithélium rénal humain
- Activation of aerobic metabolism by Amaranth oil improves heart rate variability both in athletes and patients with type 2 diabetes mellitus
- Resistance to diabetes-promoting lifestyle factors -- what is the mechanism?
- Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?
- HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality.
- Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival
- Apoptosis in pancreatic β-islet cells in Type 2 diabetes.
- Acidic intracellular Ca(2+) stores and caveolae in Ca(2+) signaling and diabetes.
- Endoplasmic Reticulum Stress Promotes Autophagy and Apoptosis and Reduces Chemotherapy Resistance in Mutant p53 Lung Cancer Cells
- Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes
- Inflammation in type 2 diabetes and the neuroendocrine role of IL-18
- Type 2 diabetes mellitus
- Targeting type 2 diabetes.
- The unfolded protein response in mouse cerebral cortex.
- HDLs, diabetes, and metabolic syndrome.
- Protein tyrosine phosphatase 1B (PTP1B) and obesity.
- Regulation of Atp10c , a Novel Type 4 P-type ATPase, in 3T3-L1 Mouse Adipocytes
- Impacts de perturbations de l'homéostasie lipidique sur la fonctionnalité de la voie de secrétion chez la levure Saccharomyces cerevisiae
Related papers
No related papers recorded.