Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells
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Summary
It is concluded that aglycemia modulates the hypoxic HIF signaling toward a non-canonical response that is unable to carry out complete PDH phosphorylation, allowing a high pyruvate input for OXPHOS from the elevated glycolysis, which together with ongoing glutaminolysis maintain a virtually unchanged respiration.
- Type
- article
- Published
- 2015-10-08
- Cited by
- 21
- References
- 65
- OpenAlex
- https://openalex.org/W1921687551
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5421688
Keywords
Glycolysis, Oxidative phosphorylation, Glutaminolysis, Warburg effect, Biochemistry
References
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Cited by
- Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells.
- Integration of superoxide formation and cristae morphology for mitochondrial redox signaling.
- Background levels of neomorphic 2-hydroxyglutarate facilitate proliferation of primary fibroblasts.
- Antioxidant mechanism of mitochondria-targeted plastoquinone SkQ1 is suppressed in aglycemic HepG2 cells dependent on oxidative phosphorylation.
- Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression
- Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia
- Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling
- Mitochondrial cristae narrowing upon higher 2-oxoglutarate load.
- Mitochondrial Superoxide Production Decreases on Glucose-Stimulated Insulin Secretion in Pancreatic β Cells Due to Decreasing Mitochondrial Matrix NADH/NAD+ Ratio
- Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells
- Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling
- Mitochondrial oxidative phosphorylation became functional under aglycemic hypoxia conditions in A549 cells
- Multifaceted roles of aerobic glycolysis and oxidative phosphorylation in hepatocellular carcinoma
- Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
- Mitochondrial Dynamics and Cristae Shape Changes During Metabolic Reprogramming
- Pitfalls of Mitochondrial Redox Signaling Research
- Mitochondrial Physiology of Cellular Redox Regulations.
- Saxagliptin protects against hypoxia-induced damage in H9c2 cells.
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