Cellular and molecular mechanisms in the hypoxic tissue: role of HIF‐1 and ROS
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Summary
New developments in HIF‐mediated O2 sensing mechanisms and their interactions with reactive oxygen species–generating pathways in normal and abnormal physiology are summarized.
- Type
- review
- Published
- 2013-08-01
- Cited by
- 139
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1500739443
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33229504
Keywords
Reactive oxygen species, Cell biology, Transcription factor, Mediator, Oxidative phosphorylation
References
- RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.
- The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors*
- Activation of Hif1α by the Prolylhydroxylase Inhibitor Dimethyoxalyglycine Decreases Radiosensitivity
- A potential role for reactive oxygen species and the HIF-1α-VEGF pathway in hypoxia-induced pulmonary vascular leak
- Development of aptitude at altitude.
- Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis.
- Hypoxia signalling through mTOR and the unfolded protein response in cancer
- Elevated serum myeloperoxidase activities are significantly associated with the prevalence of ACS and High LDL-C levels in CHD patients.
- Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.
- Redox signaling in cardiac myocytes
- Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
- The Hypoxic Testicle: Physiology and Pathophysiology
- A PROSPECTIVE, OBSERVATIONAL STUDY OF SOLUBLE FLT-1 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN SEPSIS
- Nitric oxide and superoxide: interference with hypoxic signaling.
- Microenvironment and Radiation Therapy
- Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability
- Nitric oxide and oxidative stress in vascular disease
- Protein–protein interactions involving IKKγ (NEMO) that promote the activation of NF‐κB
- Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.
- Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells.
Cited by
- The Warburg Effect: Evolving Interpretations Of An Established Concept
- Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation
- Responses of peripheral blood mononuclear cells to moderate exercise and hypoxia
- Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma
- Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells
- Novel relationships between oxidative stress and angiogenesis-related factors in sepsis: New biomarkers and therapies
- Hypoxia-sensitive pathways in inflammation-driven fibrosis.
- Upregulation of HIF-1α Via Activation of ERK and PI3K Pathway Mediated Protective Response to Microwave-Induced Mitochondrial Injury in Neuron-Like Cells
- Oxidative stress and free radicals in COPD – implications and relevance for treatment
- Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer’s disease
- Ω3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Rats
- Genetic modification of hypoxia signaling in animal models and its effect on cancer
- NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity.
- Oxygen and viruses: a breathing story.
- Toll‐like receptors hit calcium
- Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2
- The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction.
- Endotoxin‐induced acute lung injury in mice is protected by 5,7‐dihydroxy‐8‐methoxyflavone via inhibition of oxidative stress and HIF‐1α
- Hippocampal Neuroprotection by Minocycline and Epigallo‐Catechin‐3‐Gallate Against Cardiopulmonary Bypass‐Associated Injury
- Protective effects of polyunsatutared fatty acids supplementation against testicular damage induced by intermittent hypobaric hypoxia in rats
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