A model for p53-induced apoptosis
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Summary
Examination of transcripts induced by p53 expression before the onset of apoptosis stimulated additional biochemical and pharmacological experiments suggesting that p53 results in apoptosis through a three-step process: the transcriptional induction of redox-related genes; the formation of reactive oxygen species; and the oxidative degradation of mitochondrial components, culminating in cell death.
- Type
- article
- Published
- 1997-09-18
- Cited by
- 2,602
- References
- 27
- OpenAlex
- https://openalex.org/W1657827244
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4429638
Keywords
Apoptosis, Programmed cell death, Cell biology, Biology, Gene
References
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- Definition of a consensus binding site for p53
- Genetic determinants of p53-induced apoptosis and growth arrest.
- Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
- Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
- The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis.
- The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
Cited by
- Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
- Enhancing CHO cell productivity through the stable depletion of microRNA-23
- Signalling steps in apoptosis by ether lipids
- Signal transduction and apoptosis pathways as therapeutic targets.
- Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates.
- Disruption of actin microfilaments by cytochalasin D leads to activation of p53
- Delivery of Cell Cycle Genes to Block Astrocytoma Growth
- Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
- Regulation of expression of galectin-7 in human nasal polyps by budesonide.
- The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9
- The three‐dimensional map of microsomal glutathione transferase 1 at 6 Å resolution
- PUMA induces the rapid apoptosis of colorectal cancer cells.
- The biology of apoptosis.
- P53-responsive genes and the potential for cancer diagnostics and therapeutics development.
- Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)
- E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination.
- Expression of Maspin in Colon Cancers: Its Relationship with p53 Expression and Microvessel Density
- Antiapoptotic Action of Focal Adhesion Kinase (FAK) Against Ionizing Radiation
- Galectins and neuroinflammation.
- Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo
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