Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
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Summary
Select cell cycle checkpoint signaling pathways will be discussed and how different components of these pathways are regulated by exogenous and endogenous agents, with focus on the p53 tumor suppressor signaling.
- Type
- review
- Published
- 2002-12-01
- Cited by
- 502
- References
- 43
- OpenAlex
- https://openalex.org/W6853850
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26300946
Keywords
Cell biology, Cell cycle checkpoint, Cell cycle, Biology, Signal transduction
References
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- Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
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- A model for p53-induced apoptosis
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- Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.
- The role of ATM in DNA damage responses and cancer
- Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells
- Disruption of p53 in human cancer cells alters the responses to therapeutic agents.
- Selective radiosensitization of p53–deficient cells by caffeine–mediated activation of p34cdc2 kinase
- The cellular response to p53: the decision between life and death
- Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
- p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes
- p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.
- p53 transcriptional activity is essential for p53‐dependent apoptosis following DNA damage
- Checkpoints: controls that ensure the order of cell cycle events.
- PUMA, a novel proapoptotic gene, is induced by p53.
- p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest.
Cited by
- Discovering inner ear and central auditory system cellular pathways that might contribute to age- related hearing loss
- Acanthamoeba induces cell-cycle arrest in host cells.
- Zinc deficiency depresses p21 gene expression: inhibition of cell cycle progression is independent of the decrease in p21 protein level in HepG2 cells.
- Propolin H from Taiwanese propolis induces G1 arrest in human lung carcinoma cells.
- Yeast aging and apoptosis.
- Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis
- Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells
- p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision
- Multiple siRNA delivery against cell cycle and anti-apoptosis proteins using lipid-substituted polyethylenimine in triple-negative breast cancer and nonmalignant cells.
- ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro
- Knockdown of STEAP1 inhibits cell growth and induces apoptosis in LNCaP prostate cancer cells counteracting the effect of androgens
- Chinese Propolis Exerts Anti-Proliferation Effects in Human Melanoma Cells by Targeting NLRP1 Inflammatory Pathway, Inducing Apoptosis, Cell Cycle Arrest, and Autophagy
- Biological evaluation of chlorogold complexes as potential anti-tumoural compounds: unraveling mechanisms of action
- Investigation of Improvements in the Quality of Life for Cancer Patients
- The co-modulation of apoptosis and the cell cycle
- Regulatory effects of deguelin on proliferation and cell cycle of Raji cells
- Expression of Ki-67, Bcl-2, Survivin and p53 Proteins in Patients with Pulmonary Carcinoma.
- G1 and S-phase checkpoints, chromosome instability, and cancer.
- Role of Tyrosyl-DNA Phosphodiesterase I (TDP1) as a Prognostic and Predictive Factor in Malignant Glioma
- The effects of transglutaminase 2 modulation on endothelial cell biology: focus on celiac disease pathogenesis
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