Expression of Maspin in Colon Cancers: Its Relationship with p53 Expression and Microvessel Density
Explore this paper's citation graph
Summary
Maspin expression in colon cancer is demonstrated with a sequential decreased expression rate from adenoma to metastatic carcinomas, which signifies the tumor suppressive function of maspin, and an inverse correlation with p53 and microvesel density, which indicates the regulatory effect of p53 on maspIn and anti-angiogenesis effect of mspin.
- Type
- article
- Published
- 2002-08-01
- Cited by
- 73
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W12184537
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9592594
Keywords
Computer science
References
- Maspin: a tumor suppressing serpin.
- The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
- Maspin is an angiogenesis inhibitor
- Production, purification, and characterization of recombinant maspin proteins.
- A model for p53-induced apoptosis
- Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells.
- The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21WAF1/CIP1 induction, G2/M arrest, and apoptosis.
- RNA genetics of breast cancer: maspin as paradigm.
- Epigenetic silencing of maspin gene expression in human breast cancers
- The Tumor Suppressor Maspin Does Not Undergo the Stressed to Relaxed Transition or Inhibit Trypsin-like Serine Proteases.
- The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.
- Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.
- Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer.
- Measuring Scales for Pocket Spectroscopes
- A somatic cell hybrid panel for regional mapping of human chromosome 18.
- High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma
- p53 Regulates the Expression of the Tumor Suppressor Gene Maspin*
- maspin suppresses the invasive phenotype of human breast carcinoma.
- Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.
- Report of the first international workshop on human chromosome 18 mapping.
Cited by
- Practical value of the new system for Maspin assessment, in colorectal cancer.
- Maspin expression and subcellular localization in invasive ductal carcinoma of the breast: Prognostic significance and relation to microvessel density.
- Estimation of maspin's subcellular localization in invasive ductal breast cancer via light microscopy and computerized image analysis: a comparative study.
- Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer.
- Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas.
- The Tumor-Suppressive Role Of Secreted Maspin Via The Exosomes
- Roles of novel biomarkers in progression of cutaneous squamous cell carcinoma
- Chapter 14. Measuring intratumoral microvessel density.
- Serpin B5 is a CEA‐interacting biomarker for colorectal cancer
- The promise and challenge toward the clinical application of maspin in cancer.
- Elevated nuclear maspin expression is associated with microsatellite instability and high tumour grade in colorectal cancer
- Expressions of maspin, P53 and Skp2 in colorectal tumors and their clinicopathological significance
- Expression of Maspin, a Cancer Suppressor Gene, in Patients with Early Colon Cancer
- Nuclear maspin expression as a predictive marker for fluorouracil treatment response in colon cancer
- Nuclear Maspin expression is associated with response to adjuvant 5‐fluorouracil based chemotherapy in patients with stage III colon cancer
- Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas.
- Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node‐positive colonic cancer
- Clinical significance of Maspin promoter methylation and loss of its protein expression in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression
- Aberrant maspin expression is involved in early carcinogenesis of gallbladder cancer
- Maspin expression and localization impact on angiogenesis and prognosis in ovarian cancer.
Related papers
No related papers recorded.