Cellular senescence in aging and age-related disease: from mechanisms to therapy
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Summary
Current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and age-related diseases as well as disease therapy are discussed.
- Type
- review
- Published
- 2015-12-01
- Cited by
- 2,129
- References
- 167
- Access
- Open access
- OpenAlex
- https://openalex.org/W2193792657
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205395981
Keywords
Senescence, Paracrine signalling, Biology, Disease, Autocrine signalling
References
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Cited by
- Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
- Origin of Cancer: An Information, Energy, and Matter Disease
- Melatonin regulates PARP1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
- ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer
- Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts
- Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress.
- Therapeutic Potential and Cellular Mechanisms of Panax Notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases
- Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes
- Senescent cells and osteoarthritis: a painful connection
- Targeting Vascular Inflammaging with Amlodipine for Atherosclerosis Prevention.
- Epithelial-mesenchymal transition to Mitigate Age-Related Progression in Lung Cancer.
- Cancer-associated fibroblasts in hepatocellular carcinoma.
- Autophagy and kidney aging.
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- Accelerated Vascular Aging as a Paradigm for Hypertensive Vascular Disease: Prevention and Therapy.
- Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
- Cellular senescence and aging.
- IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases.
- Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
- Rejuvenating Muscle Stem Cell Function: Restoring Quiescence and Overcoming Senescence
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