The microenvironment of the tumour–host interface
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Summary
A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.
- Type
- review
- Published
- 2001-05-17
- Cited by
- 2,380
- References
- 66
- OpenAlex
- https://openalex.org/W1656339735
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4394630
Keywords
Microecology, Extracellular matrix, Stroma, Tumor microenvironment, Host (biology)
References
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- Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.
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- Farnesyltransferase Inhibitors: Preclinical Development
- Integrins and anoikis.
- An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation
- Differential stromal regulation of MMP-1 expression in benign and malignant keratinocytes.
- Dynamic remodeling of the vascular bed precedes tumor growth: MLS ovarian carcinoma spheroids implanted in nude mice.
- Mesenchymal reprogramming of adult human epithelial differentiation.
- Vascular permeability factor (Vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast
- Release of biological activities from quiescent fibronectin by a conformational change and limited proteolysis by matrix metalloproteinases.
- The multiple roles of tumour stroma
Cited by
- A study of a proline specific seprase activity from mammalian serum
- Signal transduction targets in invasion
- Role of Myofibroblasts at the Invasion Front
- Selective targeting of tumoral vasculature: Comparison of different formats of an antibody (L19) to the ED‐B domain of fibronectin
- Involvement of large tenascin-C splice variants in breast cancer progression.
- Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse
- Increased expression and activation of gelatinolytic matrix metalloproteinases is associated with the progression and recurrence of human cervical cancer.
- Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior
- Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
- Common gene polymorphisms, cancer progression and prognosis.
- Impact of proteomics on bladder cancer research.
- Organ-selective chemoresistance in metastasis from human breast cancer cells: inhibition of apoptosis, genetic variability and microenvironment at the metastatic focus.
- Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors
- Induction of CD4+ and CD8+ T-Cell Responses to the Human Stromal Antigen, Fibroblast Activation Protein: Implication for Cancer Immunotherapy
- Effector memory T cells, early metastasis, and survival in colorectal cancer.
- Proteomic analysis of tumor establishment and growth in the B16-F10 mouse melanoma model.
- Field cancerization in oral lichen planus.
- Target validation using RNA interference in solid tumors.
- Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease.
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