Mutants in the Saccharomyces cerevisiae RAS2 gene influence life span, cytoskeleton, and regulation of mitosis.
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Summary
The phenotypic characteristics of the RAS2ala18,val19 mutation could be causative for the previously observed rapid loss of viability of these cells in stationary phase.
- Type
- article
- Published
- 1997-08-01
- Cited by
- 56
- References
- 23
- OpenAlex
- https://openalex.org/W2011398234
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25294477
Keywords
Mutant, Biology, Phenotype, Mitosis, Saccharomyces cerevisiae
References
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- Conserved and unique amino acid residues in the domains of the growth hormones. Flounder growth hormone deduced from the cDNA sequence has the minimal size in the growth hormone prolactin gene family.
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- Prolongation of the yeast life span by the v‐Ha‐RAS oncogene
- RAS2 of Saccharomyces cerevisiae is required for gluconeogenic growth and proper response to nutrient limitation.
- Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.
- Mammalian and yeast ras gene products: biological function in their heterologous systems.
- Life Span of Individual Yeast Cells
- Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS.
- ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae
- The GTPase superfamily: a conserved switch for diverse cell functions
- In yeast, RAS proteins are controlling elements of adenylate cyclase.
- Function for Ras in sight
- Genetic analysis of aging in Saccharomyces cerevisiae.
- Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.
- Calendar life span versus budding life span of Saccharomyces cerevisiae.
- Regulators and effectors of ras proteins.
- Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase
- Review: To bud until death: The genetics of ageing in the yeast, Saccharomyces
Cited by
- Yeast aging and apoptosis.
- Aging Research in Yeast
- DNA damage and DNA replication stress in yeast models of aging.
- The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1
- Isolation of a haploid from an industrial Chinese rice wine yeast for metabolic engineering manipulation
- The role of mitochondria in the aging processes of yeast.
- Functional Analysis of the Yku Complex in Telomere Length Regulation
- Ras/PKA signal transduction pathway participates in the regulation of Saccharomyces cerevisiae cell apoptosis in an acidic environment
- A comparison of the aging and apoptotic transcriptome of Saccharomyces cerevisiae.
- Senescence and apoptosis in yeast mother cell-specific aging and in higher cells: a short review.
- Yeast hypertrophy: cause or consequence of aging? Reply to Bilinski et al.
- The influence of oxygen toxicity on yeast mother cell-specific aging.
- The oncogenicRAS2val19 mutation locks respiration, independently of PKA, in a mode prone to generate ROS
- The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration
- GRC5 and NMD3 function in translational control of gene expression and interact genetically
- Carbon source‐dependent regulation of cell growth by murine protein kinase C epsilon expression in Saccharomyces cerevisiae
- The actin cytoskeleton, RAS-cAMP signaling and mitochondrial ROS in yeast apoptosis.
- Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development.
- Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species‐dependent routes
- End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging
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