Regulation of the initiation step of DNA replication by cyclin-dependent kinases
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Summary
This review overviews the regulation of DNA replication in the eukaryotic cell cycle, focusing specifically on how CDKs regulate the initiation step ofDNA replication.
- Type
- review
- Published
- 2010-08-05
- Cited by
- 73
- References
- 74
- OpenAlex
- https://openalex.org/W1998323196
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36084659
Keywords
Origin recognition complex, Pre-replication complex, Licensing factor, Eukaryotic DNA replication, DNA re-replication
References
- Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.
- DNA replication and human disease
- Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
- Deregulated cyclin E induces chromosome instability
- Overexpression of cyclin D1 enhances gene amplification.
- Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain.
- CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.
- GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
- Structure and Function of the c-myc DNA-unwinding Element-binding Protein DUE-B*
- Regulation of early events in chromosome replication.
- S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
- CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis.
- Eukaryotic DNA replication control: lock and load, then fire.
- GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication
- Dbf4p, an Essential S Phase-Promoting Factor, Is Targeted for Degradation by the Anaphase-Promoting Complex
- Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae
- Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
- RecQ helicases: guardian angels of the DNA replication fork
- Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.
- Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.
Cited by
- Anticancer properties of novel aminoacetonitrile derivative monepantel (ADD 1566) in pre-clinical models of human ovarian cancer.
- Mediators of pre-mRNA splicing regulate sister chromatid cohesion in mammalian cells
- RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells
- Structural and biochemical studies of MCM proteins
- Crosstalk between kinases, phosphatases and miRNAs in cancer.
- A variable fork rate affects timing of origin firing and S phase dynamics in Saccharomyces cerevisiae.
- CHEK again: revisiting the development of CHK1 inhibitors for cancer therapy.
- DNA replication stress: causes, resolution and disease.
- A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA
- ATPase-Dependent Quality Control of DNA Replication Origin Licensing
- Hpz1 Modulates the G1-S Transition in Fission Yeast
- Initiation of chromosomal DNA replication in eukaryotic cells; contribution of yeast genetics to the elucidation.
- Safeguarding genetic information in Drosophila
- Highly organized DnaA–oriC complexes recruit the single-stranded DNA for replication initiation
- Helicase activation and establishment of replication forks at chromosomal origins of replication.
- Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human Cells
- 1α,25 dihydroxi-vitamin D₃ modulates CDK4 and CDK6 expression and localization.
- Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination.
- The Histone Chaperone Facilitates Chromatin Transcription (FACT) Protein Maintains Normal Replication Fork Rates*
- Controlling DNA replication origins in response to DNA damage – inhibit globally, activate locally
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- Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases.
- TORC1 signaling regulates DNA replication via DNA replication protein levels.
- Regulation of DNA Replication Machinery by Mrc1 in Fission Yeast
- Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle
- Dynamics of pre-replication complex proteins during the cell division cycle.
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