Molecular insight into the PCNA-binding mode of FBH1
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Summary
The structural basis for the molecular recognition of two distinctly different motifs of FBH1, FBH1PIP and FBH1APIM, by PCNA is reported, revealing overlapped FBH1PIP and FBH1APIM binding sites of PCNA and the dominant contribution of FBH1PIP in this interaction.
- Type
- article
- Published
- 2023-03-01
- Cited by
- 9
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W4361208638
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:257826939
Keywords
Proliferating cell nuclear antigen, Helicase, DNA replication, DNA, Homologous recombination
References
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- Structural and Mechanistic Insight into DNA Unwinding by Deinococcus radiodurans UvrD
- PCNA: structure, functions and interactions
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- The puzzle of PCNA's many partners
- FBH1 Catalyzes Regression of Stalled Replication Forks.
- FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress
- PCNA, the maestro of the replication fork.
- Nuclear Dynamics of PCNA in DNA Replication and Repair
- Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair
- The Human F-Box DNA Helicase FBH1 Faces Saccharomyces cerevisiae Srs2 and Postreplication Repair Pathway Roles
- Overview of the CCP4 suite and current developments
- CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
- Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities
- iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM
Cited by
- F-box DNA Helicase 1 (FBH1) Contributes to the Destabilization of DNA Damage Repair Machinery in Human Cancers
- Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.
- The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery
- FBH1 and the replication stress response: Implications for genome stability and cancer development
- Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1
- Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1
- The bacterial DNA sliding clamp, -clamp structure, interactions, dynamics and drug discovery
- FBH1 Reverses Stalled Replication Forks via Sequential Unwinding of Nascent Strands
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