Maneuvers on PCNA Rings during DNA Replication and Repair
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Summary
An overview of post-translational modifications on both PCNA and PCNA-interacting proteins is provided and their relevance for the regulation of the dynamic processes of DNA replication and repair is discussed.
- Type
- review
- Published
- 2018-08-01
- Cited by
- 75
- References
- 192
- Access
- Open access
- OpenAlex
- https://openalex.org/W2887036946
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52051620
Keywords
Proliferating cell nuclear antigen, Processivity, DNA replication, Biology, DNA polymerase delta
References
- Proliferating cell nuclear antigen structure and interactions: too many partners for one dancer?
- Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage
- PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
- Structure of p15PAF–PCNA complex and implications for clamp sliding during DNA replication and repair
- Crystal structure of human PCNA in complex with the PIP box of DVC1.
- Characterization of human translesion DNA synthesis across a UV-induced DNA lesion
- The PyMOL Molecular Graphics System
- The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
- Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response
- Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases
- Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA
- Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.
- Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells
- Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.
- PCNA is ubiquitinated by RNF8
- Ubiquitin family modifications and template switching
- Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.
- Integrated proteomic analysis of post-translational modifications by serial enrichment
- PCNA controls establishment of sister chromatid cohesion during S phase.
- Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling
Cited by
- APIM-Mediated REV3L–PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells
- H3K9 Promotes Under-Replication of Pericentromeric Heterochromatin in Drosophila Salivary Gland Polytene Chromosomes
- The PCNA interaction motifs revisited: thinking outside the PIP-box
- Proliferating cell nuclear antigen-agarose column: A tag-free and tag-dependent tool for protein purification affinity chromatography.
- Mfn2 inhibits proliferation and cell-cycle in Hela cells via Ras-NF-κB signal pathway
- DNA polymerase ζ in DNA replication and repair
- The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase
- Discovery of Inhibitors for Proliferating Cell Nuclear Antigen Using a Computational-Based Linked-Multiple-Fragment Screen
- Multilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism
- ACSS2/AMPK/PCNA pathway‑driven proliferation and chemoresistance of esophageal squamous carcinoma cells under nutrient stress.
- Fetal liver mesenchymal stem cells restore ovarian function in premature ovarian insufficiency by targeting MT1
- Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation.
- Regulation of Translesion DNA Synthesis in Mammalian Cells.
- Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo
- Genomic alterations and abnormal expression of APE2 in multiple cancers
- Robust high-throughput assays to assess discrete steps in ubiquitination and related cascades
- Sensitive and selective monitoring of the DNA damage-induced intracellular p21 protein and unraveling the role of the p21 protein in DNA repair and cell apoptosis by surface plasmon resonance.
- Human PCNA Structure, Function, and Interactions
- PCNA antagonizes cohesin-dependent roles in genomic stability
- Histone H3K79 demethylation by KDM2B facilitates proper DNA replication through PCNA dissociation from chromatin
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