DNA–protein crosslink repair
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Summary
DNA–protein crosslinks are highly toxic DNA adducts, but whether dedicated DPC-repair mechanisms exist was until recently unknown, but discoveries made in yeast and Xenopus laevis revealed a protease-based DNA-repair pathway specific for DPCs.
- Type
- review
- Published
- 2015-07-01
- Cited by
- 96
- References
- 57
- OpenAlex
- https://openalex.org/W1918696497
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36961855
Keywords
DNA repair, Biology, Xenopus, Gene, DNA
References
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- Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
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- Nucleotide excision repair and homologous recombination systems commit differentially to the repair of DNA-protein crosslinks.
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- Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks
- Spartan deficiency causes genomic instability and progeroid phenotypes
- Formaldehyde-induced sister chromatid exchanges in vitro and the influence of the exogenous metabolizing systems S9 mix and primary rat hepatocytes
- DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage
Cited by
- Crystal structure of human PCNA in complex with the PIP box of DVC1.
- Effects of conformational ordering on protein/polyelectrolyte electrostatic complexation: ionic binding and chain stiffening
- Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication
- Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin
- Characterization of a novel DNA binding domain in the N-terminus of BRCA2 and evaluation of BRCA2 variants identified in breast cancer patients in the same region
- Bifunctional alkylating agent-mediated MGMT-DNA cross-linking and its proteolytic cleavage in 16HBE cells.
- DNA Damage and Pulmonary Hypertension
- Do chromosome changes in blood cells implicate formaldehyde as a leukemogen?
- Timeless insights into prevention of acetaldehyde genotoxicity?
- Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
- Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair
- Conformational Transition of Polyelectrolyte As Influenced by Electrostatic Complexation with Protein.
- SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks
- Functional Toxicogenomic Profiling Expands Insight into Modulators of Formaldehyde Toxicity in Yeast
- Radiation-induced DNA-protein cross-links: Mechanisms and biological significance.
- Site-specific covalent capture of human O6-alkylguanine-DNA-alkyltransferase using single-stranded intrastrand cross-linked DNA.
- DNA-dependent protease activity of human Spartan facilitates replication of DNA–protein crosslink-containing DNA
- Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis
- Non-enzymatic molecular damage as a prototypic driver of aging
- Targeting a Common Enemy: Toxic Cellular Mechanism of Novel Anti-cancer Agents that Alter DNA and Transcription
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