AKT/PKB signaling: navigating downstream.
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Summary
Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.
- Type
- review
- Published
- 2007-06-29
- Cited by
- 6,178
- References
- 114
- Access
- Open access
- OpenAlex
- https://openalex.org/W1984621921
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9466184
Keywords
Protein kinase B, Biology, Proto-Oncogene Proteins c-akt, Cell biology, AKT1
References
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- Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs*
- GSK3 takes centre stage more than 20 years after its discovery.
- Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells.
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- Akt regulates growth by directly phosphorylating Tsc2
- Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
Cited by
- Akt inhibition enhances the cytotoxic effect of apigenin in combination with PLX4032 in anaplastic thyroid carcinoma cells harboring BRAFV600E
- The role and regulation of PAK isoforms in cancer cell migration
- Oleanolic acid but not ursolic acid induces cell death in HepG2 cells under starvation-induced autophagy
- Signaling circuits in early B-cell development.
- Primary resistance to ATP-competitive mTOR inhibitors for the treatment of solid tumors
- The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis.
- Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
- A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size.
- PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum
- Phosphoinositide 3-Kinase p110δ Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses1
- High immunohistochemical expression of p‐AKT predicts inferior survival in patients with diffuse large B‐cell lymphoma treated with immunochemotherapy
- Regulation of Adipocyte Differentiation by Distinct Subcellular Pools of Protein Kinase B (PKB/Akt)*
- Compartmentation of GAPDH.
- Biological Rationale and Current Clinical Experience With Anti-Insulin-Like Growth Factor 1 Receptor Monoclonal Antibodies in Treating Sarcoma: Twenty Years From the Bench to the Bedside
- Platelet Microparticles Enhance the Vasoregenerative Potential of Angiogenic Early Outgrowth Cells After Vascular Injury
- Effect of collagen I and aortic carboxypeptidase-like protein on 3T3-L1 adipocyte differentiation.
- From man to mouse and back again: advances in defining tumor AKTivities in vivo
- Contribution of PKB/AKT signaling to thyroid cancer.
- Activation of miR-31 function in already-established metastases elicits metastatic regression.
- Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab
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