Krüppel-Like Factor 4 Acts as an Oncogene in Colon Cancer Stem Cell-Enriched Spheroid Cells
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Summary
C culturing DLD-1 cells in serum-free medium enriches CSCs and the expression of KLF4 is essential for the characteristics of C SCs in D LD-1; thus KLF 4 can be a potential therapeutic target for treating colon cancer.
- Type
- article
- Published
- 2013-02-13
- Cited by
- 119
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2061747533
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16100030
Keywords
KLF4, Cancer stem cell, Stem cell, Cancer research, Induced pluripotent stem cell
References
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- Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
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- Krüppel-like factor 4 negatively regulates β-catenin expression and inhibits the proliferation, invasion and metastasis of gastric cancer.
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- EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis
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- Detection and Characterization of CD133+ Cancer Stem Cells in Human Solid Tumours
- Identification and expansion of human colon-cancer-initiating cells
- C‐terminal Tensin‐like (CTEN) is an oncogene which alters cell motility possibly through repression of E‐cadherin in colorectal cancer
- ADP-Ribosylarginine Hydrolase Regulates Cell Proliferation and Tumorigenesis
Cited by
- A reliable method for the sorting and identification of ALDHhigh cancer stem cells by flow cytometry
- Isolation and characterisation of colon cancer stem cells and the effects of epigenetic modulation on pluripotent markers
- Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients.
- Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression
- Metastasis blood test by flow cytometry: In vivo cancer spheroids and the role of hypoxia
- Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival
- Different roles for p16INK4a‐Rb pathway and INK4a/ARF methylation between adenocarcinomas of gastric cardia and distal stomach
- A study of embryonic stem cell‐related proteins in human astrocytomas: Identification of Nanog as a predictor of survival
- Global Microrna Gene Expression Profiles Analysis And Possible Role Of Microrna-5p And 3p Pairs In Human Colon Cancer Cells
- Reprogramming cancer cells: a novel approach for cancer therapy or a tool for disease-modeling?
- miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer
- Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma.
- Attenuation of Krüppel-Like Factor 4 Facilitates Carcinogenesis by Inducing G1/S Phase Arrest in Clear Cell Renal Cell Carcinoma
- Oncogenesis and induced pluripotency – commonalities of signalling pathways
- The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with chemotherapy to target colon cancer stem-like cells.
- Role of Krüppel-like factors in cancer stem cells
- B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor
- Loss of cytoplasmic KLF4 expression is correlated with the progression and poor prognosis of nasopharyngeal carcinoma
- Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?
- Doxycycline Inducible Kruppel-Like Factor 4 Lentiviral Vector Mediates Mesenchymal to Epithelial Transition in Ovarian Cancer Cells
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