Natural selection on protein-coding genes in the human genome

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Summary

Comparisons of DNA polymorphism within species to divergence between species enables the discovery of molecular adaptation in evolutionarily constrained genes as well as the differentiation of weak from strong purifying selection, and finds strong evidence that natural selection has shaped the recent molecular evolution of the authors' species.

Type
article
Published
2005-10-20
Cited by
805
References
26

Keywords

Biology, Negative selection, Natural selection, Gene, Genetics

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