Natural selection on protein-coding genes in the human genome
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Summary
Comparisons of DNA polymorphism within species to divergence between species enables the discovery of molecular adaptation in evolutionarily constrained genes as well as the differentiation of weak from strong purifying selection, and finds strong evidence that natural selection has shaped the recent molecular evolution of the authors' species.
- Type
- article
- Published
- 2005-10-20
- Cited by
- 805
- References
- 26
- OpenAlex
- https://openalex.org/W1972673599
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4423768
Keywords
Biology, Negative selection, Natural selection, Gene, Genetics
References
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- Population Genetics of Polymorphism and Divergence for Diploid Selection Models With Arbitrary Dominance
- Haplotype Variation and Linkage Disequilibrium in 313 Human Genes
Cited by
- Genomics of the evolutionary process.
- Positive selection in alternatively spliced exons of human genes.
- Adaptive evolution in rodent seminal vesicle secretion proteins.
- Pervasive Natural Selection in the Drosophila Genome?
- Characterising and Predicting Haploinsufficiency in the Human Genome
- Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
- Genetic comparisons yield insight into the evolution of enamel thickness during human evolution.
- Molecular Characterization and Expression Analysis of Creatine Kinase Muscle (CK-M) Gene in Horse
- Geographically patterned variation in diapause and its relationship to other climate-associated phenotypes and genotypes of Drosophila americana
- Understanding Human Demography And Its Implications For The Detection And Dynamics Of Natural Selection
- The teleost taar family of olfactory receptors: From rapidly evolving receptor genes to ligand-induced behavior
- Evolutionary analysis of mammalian genomes and associations to human disease
- Down-regulation of mast cell responses through ITIM containing inhibitory receptors.
- Genetic variation within the Daphnia pulex genome
- Towards Biomedical Data Integration for Analyzing the Evolution of Cognition
- Genómica evolutiva de la regulación transcripcional en las principales familias multigénicas del sistema quimiosensorial de Drosophila
- Expression variation in lysosomal storage disorder genes
- The molecular evolution of teleost olfactory receptor gene families.
- Genomic Patterns of Gene Evolution.
- Evolution of DNA Recognition in a Tbrain Transcription Factor and Its Impact on Larval Neurogenesis in Echinoderms
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