Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
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Summary
The hypothesis that the cell adhesion function of the LPP3 protein is conserved across mouse and human is tested and it is shown that the intact mLpp3-RGE protein interacts with alpha(5)beta(1) and alpha(v) beta(3) integrins expressed by adjacent cells, an interaction that can be blocked by GRGDSP peptides and anti-LPP3- RGD antibodies.
- Type
- article
- Published
- 2005-09-30
- Cited by
- 32
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W16099422
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8035765
Keywords
Computer science, World Wide Web, Knowledge management, Human–computer interaction, Data science
References
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- Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells
- Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
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- Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase*
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- Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level.
Cited by
- Rôle des lipides-phosphate phosphatases dans la modulation des voies de signalisation impliquées dans les léiomyomes utérins
- Generation of a conditional Ppap2b/Lpp3 null allele
- The organization of the sphingosine 1-phosphate signaling system.
- Translating GWAS Into the Flow-Regulated Modulation of Lipid Mediator Signaling.
- A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules.
- Mice with targeted inactivation of Ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability
- Lipid phosphate phosphatases and their roles in mammalian physiology and pathology
- Lipid phosphate phosphatase (LPP3) and vascular development
- Lipid phosphate phosphatases and signaling The work was supported by the Canadian Institutes of Health Research. Published, JLR Papers in Press, December 9, 2008.
- Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and Cyclin-D1 signaling
- Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells
- Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress
- Identification of CAD candidate genes in GWAS loci and their expression in vascular cells[S]
- Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia
- LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells
- The Globoside Receptor Triggers Structural Changes in the B19 Virus Capsid That Facilitate Virus Internalization
- Lipid Phosphate Phosphatase 3 Stabilization of β-Catenin Induces Endothelial Cell Migration and Formation of Branching Point Structures
- Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia
- Unlike two peas in a pod: lipid phosphate phosphatases and phosphatidate phosphatases.
- Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon
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