The organization of the sphingosine 1-phosphate signaling system.
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Summary
Innovative genetic and chemical approaches now provide a more detailed molecular understanding of a regulated lysophospholipid ligand with a variety of autocrine, paracrine, and systemic effects in physiology and pathology, based upon selective interactions with a high affinity and selective evolutionary cluster of G-protein-coupled receptors.
- Type
- review
- Published
- 2014-01-01
- Cited by
- 25
- References
- 113
- OpenAlex
- https://openalex.org/W1775328164
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6165479
Keywords
Fingolimod, Sphingosine-1-phosphate receptor, Sphingosine, Autocrine signalling, Sphingosine-1-phosphate
References
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- The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity*
- Discovery, Design and Synthesis of the First Reported Potent and Selective Sphingosine-1-Phosphate 4 (S1P4) Receptor Antagonists
- Structure of an agonist-bound human A2A adenosine receptor
- Therapeutic Use of a Selective S1P1 Receptor Modulator Ponesimod in Autoimmune Diabetes
- Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.
- S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.
- Oral fingolimod (FTY720) for relapsing multiple sclerosis.
Cited by
- Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3
- A practical process for the preparation of [32P]S1P and binding assay for S1P receptor ligands
- Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
- Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses.
- ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex
- Design, Synthesis, and In Vitro and In Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer
- Activation mechanisms of the first sphingosine‐1‐phosphate receptor
- Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study
- Bioluminescence imaging of G protein-coupled receptor activation in living mice
- TGF-β/Smad3 pathway enhances the cardio-protection of S1R/SIPR1 in in vitro ischemia-reperfusion myocardial cell model
- Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
- Discovery and Optimization of Selective and In Vivo-Active Inhibitors of the Lyso-phosphatidylserine Lipase α/β-Hydrolase Domain-containing 12 (ABHD12)
- Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence
- ABHD12 and LPCAT3 interplay regulates a lyso-phosphatidylserine-C20:4 phosphatidylserine lipid network implicated in neurological disease
- FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain Injury
- Protective effect of the sphingosine-1 phosphate receptor agonist siponimodon disrupted blood brain barrier function.
- Ponesimod in the Treatment of Relapsing Forms of Multiple Sclerosis: An Update on the Emerging Clinical Data
- A critical review of ozanimod for the treatment of adults with moderately to severely active ulcerative colitis
- Microglia Contributes to BAF-312 Effects on Blood–Brain Barrier Stability
- Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury
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