Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile
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Summary
It is demonstrated that the Ppap2c gene is not essential for embryonic development or fertility in mice and a null mutation by gene targeting is constructed that demonstrates this.
- Type
- article
- Published
- 2000-08-01
- Cited by
- 70
- References
- 14
- OpenAlex
- https://openalex.org/W2010370015
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24643785
Keywords
Phosphatidic acid, Biology, Mutant, Cell biology, Drosophila melanogaster
References
- Cloning, expression, and chromosomal localization of a mouse gene homologous to the germ cell migration regulator wunen and to type 2 phosphatidic acid phosphatases.
- Identification of the Phosphatidic Acid Phosphatase Type 2a Isozyme as an Androgen-regulated Gene in the Human Prostatic Adenocarcinoma Cell Line LNCaP*
- Phosphatidic acid phosphatase from mammalian tissues: discovery of channel-like proteins with unexpected functions.
- The Drosophila protein Wunen repels migrating germ cells
- Identification of a novel human phosphatidic acid phosphatase type 2 isoform
- Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase*
- Mammalian Lipid Phosphate Phosphohydrolases*
- Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction.
- Disruption of a gene encoding phosphatidic acid phosphatase causes abnormal phenotypes in cell growth and abnormal cytokinesis in Saccharomyces cerevisiae.
- Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action.
- Molecular Cloning of Two Alternatively Spliced Forms of Human Phosphatidic Acid Phosphatase cDNAs that Are Differentially Expressed in Normal and Tumor Cells
- Cell migration in Drosophila.
- Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.
- Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration.
Cited by
- Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase*
- Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
- Chemical and Genetic Tools to Explore S1P Biology
- Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
- Characterisation of human airway smooth muscle cell lysophosphatidic acid receptors in asthma and health
- Generation of a conditional Ppap2b/Lpp3 null allele
- Rolle des Plasticity Related Gene-1 (PRG-1) im Gehirn der Maus
- IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.
- Role of autotaxin and lysophosphatidate in cancer progression and resistance to chemotherapy and radiotherapy
- Regulation of vascular cell function by bioactive lysophospholipids
- Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila.
- Roles of lysophosphatidic acid in cardiovascular physiology and disease.
- Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo
- Lack of lipid phosphate phosphatase-3 in embryonic stem cells compromises neuronal differentiation and neurite outgrowth
- Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
- Cloning and Characterization of Three Eimeria tenella Lipid Phosphate Phosphatases
- Drosophila gene tao-1 encodes proteins with and without a Ste20 kinase domain that affect cytoskeletal architecture and cell migration differently
- Role of the autotaxin–lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy
- Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids.
- Compartmentalizing the embryo
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