Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level.
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Summary
Transgenic overexpression of LPP-1 in mice elicited a number of unexpected phenotypic alterations without affecting several aspects of LPA signaling, which point to previously unappreciated mechanisms and roles of lipid phosphates in select organs.
- Type
- article
- Published
- 2004-03-01
- Cited by
- 66
- References
- 50
- OpenAlex
- https://openalex.org/W2074799579
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41681514
Keywords
Genetically modified mouse, Transgene, Phosphatase, Phosphate, Alkaline phosphatase
References
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Cited by
- Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
- Rôle de l’axe Autotaxine (ATX)- Acide Lysophosphatidique (LPA) et récepteur LPA1 dans la dissémination métastatique des cancers du sein
- Neuromodulatorische Wirkungen von Lysophosphatidsäure in vitro –Untersuchungen in der Maus
- The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.
- Role of autotaxin and lysophosphatidate in cancer progression and resistance to chemotherapy and radiotherapy
- Regulation of vascular cell function by bioactive lysophospholipids
- Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.
- Roles of lysophosphatidic acid in cardiovascular physiology and disease.
- Regulation and biological activities of the autotaxin-LPA axis.
- Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
- Lipid Phosphate Phosphatase-1 Regulates Lysophosphatidate-induced Fibroblast Migration by Controlling Phospholipase D2-dependent Phosphatidate Generation*
- Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
- Both Plasma Lysophosphatidic Acid and Serum Autotaxin Levels are Increased in Chronic Hepatitis C
- Lipid phosphate phosphatases: more than one way to put the brakes on LPA signaling?1
- Emerging medicinal roles for lysophospholipid signaling.
- Role of the autotaxin–lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy
- Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration.
- Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis
- Lipid phosphate phosphatases and their roles in mammalian physiology and pathology
- Lipid Phosphate Phosphatase-2 Activity Regulates S-phase Entry of the Cell Cycle in Rat2 Fibroblasts*
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