DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs
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Summary
Recent data challenge the old paradigm which suggested that a long exposure to telomerase and telomereinhibitors is necessary to induce anticancer effects and focus on mechanisms that might translate into new drug discovery.
- Type
- review
- Published
- 2000-05-01
- Cited by
- 28
- References
- 57
- OpenAlex
- https://openalex.org/W7448078
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20577076
Keywords
Telomerase, Telomere, Carcinogenesis, Telomerase reverse transcriptase, Biology
References
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- Yeast Ku as a regulator of chromosomal DNA end structure.
- Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase.
- Telomere length predicts replicative capacity of human fibroblasts.
- Specific association of human telomerase activity with immortal cells and cancer.
- Telomerase activity and telomere lengths in various cell lines: changes of telomerase activity can be another method for chemosensitivity evaluation.
- Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
Cited by
- Inhibitors of the tankyrases, triple-function targets in the cancer cell
- Detection of telomerase inhibitors based on g-quadruplex ligands by a modified telomeric repeat amplification protocol assay.
- Frequency distribution of telomere maintenance mechanisms in soft tissue sarcoma
- Application of Alizarin/Graphene-Chitosan Modified Electrode on Detection of Human Telomere DNA
- Contribution of telomere G-quadruplex stabilization to the inhibition of telomerase-mediated telomere extension by chemical ligands.
- Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations.
- DNA adducts of antitumor cisplatin preclude telomeric sequences from forming G quadruplexes
- Structural Investigations of Acridine Derivatives by CoMFA and CoMSIA Reveal Novel Insight into Their Structures toward DNA G-Quadruplex Mediated Telomerase Inhibition and Offer a Highly Predictive 3D-Model for Substituted Acridines
- Distinct G-quadruplex structures of human telomeric DNA formed by the induction of sanguinarine and nitidine under salt-deficient condition.
- A Comparison of Signaling Activities Induced by Taxol and Desoxyepothilone B
- Stability and kinetics of G-quadruplex structures
- Insight into G-DNA Structural Polymorphism and Folding from Sequence and Loop Connectivity through Free Energy Analysis
- Targeting critical regions in genomic DNA with AT-specific anticancer drugs.
- Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin
- Emerging trends in G-quadruplex biology--role in epigenetic and evolutionary events.
- Structural diversity and specific recognition of four stranded G-quadruplex DNA.
- Telomere Amount and Length Assay
- Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.
- Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat.
- Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal
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